<br>采用改进的 QuEChERS/GC-QqQ-MS/MS 方法分析乳制品中的多氯联苯 (PCB)：风险评估研究,Food Science & Nutrition

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采用改进的 QuEChERS/GC-QqQ-MS/MS 方法分析乳制品中的多氯联苯 (PCB)：风险评估研究
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2023-03-10 , DOI: 10.1002/fsn3.3269
Amin Kiani ₁ , Majid Arabameri ₂ , Nabi Shariatifar ₃ , Abbas Mehraie ₄ , Fahimeh Tooryan _{5,

6} , Ali Ghanbariasad ₇ , Saeed Shahsavari _{8,

9}

Affiliation

Department of Public Health, School of Public Health Fasa University of Medical Sciences Fasa Iran.
Food and Drug Laboratory Research Center Food and Drug Administration, Ministry of Health and Medical Education Tehran Islamic Republic of Iran Tehran Iran.
Department of Environmental Health Engineering, School of Public Health Tehran University of Medical Sciences Tehran Iran.
Department of Food Hygiene and Aquaculture, Faculty of Veterinary Medicine Ferdowsi University of Mashhad Mashhad Iran.
Department of Food Hygiene, Faculty of Veterinary Medicine Amol University of Special Modern Technologies Amol Iran.
Preventive Veterinary Medicine Graduate Group, School of Veterinary Medicine University of California Davis USA.
Department of Medical Biotechnologies Fasa University of Medical Sciences Fasa Iran.
Health Products Safety Research Center Qazvin University of Medical Sciences Qazvin Iran.
Department of Epidemiology and Biostatistics, School of Public Health Tehran University of Medical Sciences Tehran Iran.

多氯联苯 (PCB) 是一种有害化学物质，持久存在于环境中，并可在食物链中积聚。本研究的目的是使用改良的 QuEChERS（快速、简单、便宜、有效、坚固和安全）评估某些乳制品（酸奶、面团和 kashk）中的非二恶英类多氯联苯 (NDL-PCB)技术和气相色谱-三重四极杆质谱（GC-QqQ-MS/MS）方法和风险评估研究。 PCB 分析物的 LOQ（定量限）、LOD（检测限）、回收率和 RSD 分别为 0.180–0.360、0.06–0.12 ng/g 脂肪、97.45–102.63% 和 6.33–8.86%。结果显示，样本中Ʃ6-NDL-PCBs的平均浓度为15.17±3.44纳克/克脂肪，低于欧盟制定的标准水平（欧盟，40纳克/克脂肪）。样品中 PCB 的最高平均水平为 PCB 180（9.98 ± 2.04 ng/g 脂肪），PCB 的最低平均水平为 PCB 28（0.09 ± 0.06 ng/g 脂肪）。此外，结果显示，kashk 样品的 6-NDL-PCB 平均水平最高（18.66 ± 2.42 ng/g 脂肪），doogh 样品的 6-NDL-PCB 平均水平最低（12.21 ± 2.22 ng/g 脂肪）。酸奶样品中 6-NDL-PCB 的平均含量为 14.65 ± 2.02 ng/g 脂肪。热图结果显示了不同乳制品中 6-NDL-PCB 光谱指数之间的相关性。根据蒙特卡罗方法，通过计算估计每日摄入量（EDI）和增量生命癌症风险（ILCR）来进行风险评估。酸奶、酸奶和卡什克中基于第 95 个百分位的 6 种 NDL-PCB 的 EDI 值分别为 14.3、1.49 和 0.5 ng/kg.day。考虑到样品中的污染物含量低于欧盟限值，可以得出结论，饮食中暴露于6种NDL-PCBs可能不会对消费者的健康构成风险。

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Analysis of polychlorinated biphenyls (PCBs) in dairy products by modified QuEChERS/GC-QqQ-MS/MS method: A risk assessment study

Polychlorinated biphenyls (PCBs) are harmful chemicals that are persistent in the environment and can accumulate in the food chain. The purpose of the present research was to assess non-dioxin-like polychlorinated biphenyls (NDL-PCBs) in some dairy products (yogurt, doogh, and kashk) using modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) technique and gas chromatography–triple-quadrupole mass spectrometry (GC-QqQ-MS/MS) method and risk assessment study. The LOQs (limit of quantifications), LODs (limit of detections), recovery, and RSD for the PCB analytes were 0.180–0.360, 0.06–0.12 ng/g fat, 97.45–102.63%, and 6.33–8.86%, respectively. The results revealed that the mean concentrations of Ʃ6-NDL-PCBs in samples were 15.17 ± 3.44 ng/g fat, which was lower than the standard level established by European Union (EU, 40 ng/g fat). The maximum mean level was PCB 180 (9.98 ± 2.04 ng/g fat) and the minimum mean level of PCBs in samples was PCB 28 (0.09 ± 0.06 ng/g fat). Also, results showed that kashk samples had a maximum mean level of 6-NDL-PCBs (18.66 ± 2.42 ng/g fat) and doogh samples had a minimum mean level of 6-NDL-PCBs (12.21 ± 2.22 ng/g fat). The mean level of 6-NDL-PCBs in yogurt samples was 14.65 ± 2.02 ng/g fat. The heat map results showed the correlation between the spectral indices of 6-NDL-PCBs in different dairy products. According to the Monte Carlo method, risk assessment was done using calculating the Estimated Daily Intake (EDI) and Incremental Life Cancer Risk (ILCR). The EDI values of 6 NDL-PCBs based on the 95th percentile in yogurt, doogh, and kashk were 14.3, 1.49, and 0.5 ng/kg.day, respectively. Considering that the contaminant level in the samples is lower than the EU limit, it can be concluded that dietary exposure to 6 NDL-PCBs may not pose a risk to the health of consumers.

更新日期：2023-03-10

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