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Chemical Biology Approaches toward Precise Structure Control of IgG-Based Antibody-Oligonucleotide Conjugates
ChemBioChem ( IF 2.6 ) Pub Date : 2023-03-09 , DOI: 10.1002/cbic.202300077
Lin Shen 1 , Yuanyuan Wu 1 , Wenxue Xie 1 , Guangyao Chen 1 , Hang Xing 1
Affiliation  

This Concept article is centered on different chemical biology approaches that enable the production of antibody-oligonucleotide conjugates (AOCs) with accurate site-specificity and degree of conjugation. These techniques are categorized into linker-free or linker-mediated conjugations, with an emphasis on the detailed chemistry and potential applications. Additionally, the article assesses the pros and cons of each method and provides a viewpoint on the future advancements in the field of precise AOCs.

中文翻译:

基于 IgG 的抗体-寡核苷酸缀合物的精确结构控制的化学生物学方法

这篇概念文章以不同的化学生物学方法为中心,这些方法能够生产具有准确位点特异性和结合程度的抗体-寡核苷酸偶联物 (AOC)。这些技术分为无接头或接头介导的共轭,重点是详细的化学和潜在应用。此外,本文还评估了每种方法的优缺点,并对精确 AOC 领域的未来发展提出了观点。
更新日期:2023-03-09
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