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Architecting Lignin/Poly(vinyl alcohol) Hydrogel with Carbon Nanotubes for Photothermal Antibacterial Therapy
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2023-03-09 , DOI: 10.1021/acsabm.2c01061 Yeyan Chao 1, 2 , Shengkai Yu 3 , Hua Zhang 3, 4 , Dirong Gong 1 , Jingrui Li 1, 2 , Fan Wang 2 , Jing Chen 5 , Jin Zhu 2 , Jing Chen 2
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2023-03-09 , DOI: 10.1021/acsabm.2c01061 Yeyan Chao 1, 2 , Shengkai Yu 3 , Hua Zhang 3, 4 , Dirong Gong 1 , Jingrui Li 1, 2 , Fan Wang 2 , Jing Chen 5 , Jin Zhu 2 , Jing Chen 2
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With the development of antimicrobial resistance, rapid and effective killing of bacteria is required for infected wound healing after skin trauma. Herein, we reported a one-pot reaction strategy to prepare a composite hydrogel with antibacterial activity through high-efficiency photothermal therapy. We take poly(vinyl alcohol) as the matrix, and lignin-derived from biomass was introduced into the hydrogel to increase the tensile strength of the prepared hydrogel to 108.58 kPa, and the elongation at break reaches 200.8%. The electrostatic interaction between lignin and chitosan enhanced the reactivity of lignin. Carbon nanotubes endow the hydrogel with photothermal antibacterial activity that can kill more than 97% of either Escherichia coli or Staphylococcus aureus within 5 min, avoiding the problem of bacterial resistance. Experimental evaluation on mice showed that the hydrogel could effectively promote wound healing of full-thickness skin defects. The hydrogels with good mechanical properties, antioxidant activity, and excellent photothermal antibacterial ability show good potential to repair the damaged tissue and are expected to be used in the clinical transformation of wound dressing.
中文翻译：
用碳纳米管构建木质素/聚（乙烯醇）水凝胶用于光热抗菌治疗
随着抗菌素耐药性的发展，皮肤外伤后感染伤口的愈合需要快速有效地杀灭细菌。在此，我们报道了一种通过高效光热疗法制备具有抗菌活性的复合水凝胶的一锅反应策略。我们以聚乙烯醇为基质，将生物质来源的木质素引入到水凝胶中，使制备的水凝胶的拉伸强度提高到108.58 kPa，断裂伸长率达到200.8%。木质素和壳聚糖之间的静电相互作用增强了木质素的反应性。碳纳米管赋予水凝胶光热抗菌活性，可杀死超过 97% 的大肠杆菌或金黄色葡萄球菌5分钟内，避免细菌耐药问题。小鼠实验评价表明，该水凝胶可有效促进全层皮肤缺损创面愈合。水凝胶具有良好的力学性能、抗氧化活性和优异的光热抗菌能力，显示出良好的修复损伤组织的潜力，有望用于伤口敷料的临床转化。
更新日期：2023-03-09
中文翻译：
用碳纳米管构建木质素/聚（乙烯醇）水凝胶用于光热抗菌治疗
随着抗菌素耐药性的发展，皮肤外伤后感染伤口的愈合需要快速有效地杀灭细菌。在此，我们报道了一种通过高效光热疗法制备具有抗菌活性的复合水凝胶的一锅反应策略。我们以聚乙烯醇为基质，将生物质来源的木质素引入到水凝胶中，使制备的水凝胶的拉伸强度提高到108.58 kPa，断裂伸长率达到200.8%。木质素和壳聚糖之间的静电相互作用增强了木质素的反应性。碳纳米管赋予水凝胶光热抗菌活性，可杀死超过 97% 的大肠杆菌或金黄色葡萄球菌5分钟内，避免细菌耐药问题。小鼠实验评价表明，该水凝胶可有效促进全层皮肤缺损创面愈合。水凝胶具有良好的力学性能、抗氧化活性和优异的光热抗菌能力，显示出良好的修复损伤组织的潜力，有望用于伤口敷料的临床转化。
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