IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation,Allergy

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IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation
Allergy ( IF 12.6 ) Pub Date : 2023-03-08 , DOI: 10.1111/all.15705
Hyung-Ju Cho _{1,

2} , Youn Wook Chung ₃ , Sungmin Moon ₃ , Ju Hee Seo ₁ , Miran Kang ₁ , Jae Sung Nam ₁ , Sang-Nam Lee ₃ , Chang-Hoon Kim _{1,

2} , Augustine M K Choi ₄ , Joo-Heon Yoon _{1,

2,

3}

Affiliation

Allergic inflammation affects the epithelial cell populations resulting in goblet cell hyperplasia and decreased ciliated cells. Recent advances in single-cell RNA sequencing (scRNAseq) have enabled the identification of new cell subtypes and genomic features of single cells. In this study, we aimed to investigate the effect of allergic inflammation in nasal epithelial cell transcriptomes at the single-cell level.

中文翻译：

IL-4 通过改变祖细胞分化显着减少次子宫细胞和多纤毛细胞

过敏性炎症影响上皮细胞群，导致杯状细胞增生和纤毛细胞减少。单细胞 RNA 测序 (scRNAseq) 的最新进展使得能够识别新的细胞亚型和单细胞的基因组特征。在这项研究中，我们的目的是在单细胞水平上研究过敏性炎症对鼻上皮细胞转录组的影响。

更新日期：2023-03-08

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