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Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-03-07 , DOI: 10.1021/jacs.3c01231 Mingle Li 1 , Jungryun Kim 1 , Hyeonji Rha 1 , Subin Son 1 , Matthew S Levine 2 , Yunjie Xu 1 , Jonathan L Sessler 2 , Jong Seung Kim 1
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-03-07 , DOI: 10.1021/jacs.3c01231 Mingle Li 1 , Jungryun Kim 1 , Hyeonji Rha 1 , Subin Son 1 , Matthew S Levine 2 , Yunjie Xu 1 , Jonathan L Sessler 2 , Jong Seung Kim 1
Affiliation
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Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has expanded beyond the cellular level and now includes extracellular responses. In recent years, pyroptosis has attracted considerable attention due to its potential to induce host immunity. For instance, at the 2022 International Medicinal Chemistry of Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled pyroptosis activation (“PhotoPyro”), an emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share in this Perspective our views on this emerging area and expound on how and why “PhotoPyro” could trigger antitumor immunity (i.e., turning so-called “cold” tumors “hot”). In doing so, we have tried to highlight cutting-edge breakthroughs in PhotoPyro while suggesting areas for future contributions. By providing insights into the current state of the art and serving as a resource for individuals interested in working in this area, it is hoped that this Perspective will set the stage for PhotoPyro to evolve into a broadly applicable cancer treatment strategy.
中文翻译：
光子控制的焦亡激活（PhotoPyro）：抗肿瘤免疫反应的新兴触发因素
细胞焦亡是指gasdermin介导的裂解性程序性细胞死亡（PCD）的过程，其特征是促炎细胞因子的释放。我们对细胞焦亡的了解已经超出了细胞水平，现在包括细胞外反应。近年来，细胞焦亡因其诱导宿主免疫的潜力而引起了广泛关注。例如，在 2022 年国际天然活性配体金属药物化学 (MCNALMD) 会议上，许多研究人员表现出了对光子控制焦亡激活 (“PhotoPyro”) 的兴趣，这是一种新兴的焦亡工程方法，可通过光照射。鉴于这种热情，我们在本期《观点》中分享了我们对这一新兴领域的看法，并阐述了“PhotoPyro”如何以及为何能够触发抗肿瘤免疫（即将所谓的“冷”肿瘤“热”）。在此过程中，我们试图强调 PhotoPyro 的前沿突破，同时提出未来贡献的领域。通过提供对当前技术水平的见解并为有兴趣在该领域工作的个人提供资源，希望这一观点将为 PhotoPyro 发展成为广泛适用的癌症治疗策略奠定基础。
更新日期：2023-03-07
中文翻译：
光子控制的焦亡激活（PhotoPyro）：抗肿瘤免疫反应的新兴触发因素
细胞焦亡是指gasdermin介导的裂解性程序性细胞死亡（PCD）的过程，其特征是促炎细胞因子的释放。我们对细胞焦亡的了解已经超出了细胞水平，现在包括细胞外反应。近年来，细胞焦亡因其诱导宿主免疫的潜力而引起了广泛关注。例如，在 2022 年国际天然活性配体金属药物化学 (MCNALMD) 会议上，许多研究人员表现出了对光子控制焦亡激活 (“PhotoPyro”) 的兴趣，这是一种新兴的焦亡工程方法，可通过光照射。鉴于这种热情，我们在本期《观点》中分享了我们对这一新兴领域的看法，并阐述了“PhotoPyro”如何以及为何能够触发抗肿瘤免疫（即将所谓的“冷”肿瘤“热”）。在此过程中，我们试图强调 PhotoPyro 的前沿突破，同时提出未来贡献的领域。通过提供对当前技术水平的见解并为有兴趣在该领域工作的个人提供资源，希望这一观点将为 PhotoPyro 发展成为广泛适用的癌症治疗策略奠定基础。
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