An iodide-containing covalent organic framework for enhanced radiotherapy,Chemical Science

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An iodide-containing covalent organic framework for enhanced radiotherapy
Chemical Science ( IF 7.6 ) Pub Date : 2023-03-06 , DOI: 10.1039/d3sc00251a
Le-Le Zhou ₁ , Qun Guan ₁ , Wei Zhou ₂ , Jing-Lan Kan ₁ , Yu-Bin Dong ₁

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Metal-free radiosensitizers, particularly iodine, have shown promise in enhancing radiotherapy due to their suitable X-ray absorption capacities and negligible biotoxicities. However, conventional iodine compounds have very short circulating half-lives and are not retained in tumors very well, which significantly limits their applications. Covalent organic frameworks (COFs) are highly biocompatible crystalline organic porous materials that are flourishing in nanomedicine but have not been developed for radiosensitization applications. Herein, we report the room-temperature synthesis of an iodide-containing cationic COF by the three-component one-pot reaction. The obtained TDI-COF can be a tumor radiosensitizer for enhanced radiotherapy by radiation-induced DNA double-strand breakage and lipid peroxidation and inhibits colorectal tumor growth by inducing ferroptosis. Our results highlight the excellent potential of metal-free COFs as radiotherapy sensitizers.

中文翻译：

用于增强放射治疗的含碘化物共价有机框架

无金属放射增敏剂，特别是碘，由于其合适的 X 射线吸收能力和可忽略的生物毒性，在增强放射治疗方面显示出了前景。然而，传统的碘化合物循环半衰期很短，并且不能很好地保留在肿瘤中，这极大地限制了它们的应用。共价有机框架（COF）是高度生物相容性的结晶有机多孔材料，在纳米医学领域蓬勃发展，但尚未开发用于放射增敏应用。在此，我们报道了通过三组分一锅反应在室温下合成含碘化物的阳离子COF。所得TDI-COF可作为肿瘤放射增敏剂，通过辐射诱导DNA双链断裂和脂质过氧化来增强放射治疗，并通过诱导铁死亡来抑制结直肠肿瘤的生长。我们的结果凸显了无金属 COF 作为放射治疗敏化剂的巨大潜力。

更新日期：2023-03-06

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