Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.

中文翻译：

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I型胶原的仿生纤维内矿化与中间前体负载的介孔载体。

矿化介质的有限的连续补充是对矿化不足的身体组织进行基于溶液的再矿化的限制。在这里，我们报告了一个过程，该过程生成了胺官能化的介孔二氧化硅纳米颗粒，用于持续释放仿生类似物稳定的无定形磷酸钙前体。二维和三维胶原模型都可以用这些释放的流体中间体前体在纤维内矿化。这代表了将生物矿化概念转化为骨骼和牙齿的原位矿化过程的重要进展。