Eye ( IF 2.8 ) Pub Date : 2023-03-01 , DOI: 10.1038/s41433-023-02451-w
Emanuele Crincoli , Silvia Ferrara , Alexandra Miere , Riccardo Sacconi , Marco Battista , Fiammetta Catania , Eric H. Souied , Giuseppe Querques
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Objectives
To investigate the correlation between the AI-measured area of the lacquer cracks (LC) at their first detection and the occurrence of a choroidal neovascularization (CNV) during the follow-up in patients affected by pathologic myopia. Secondary outcome was the detection of a correlation between the time to onset of CNV with both baseline LC area and LC area increase during follow-up.
Methods
Optical coherence tomography (OCT) acquisitions of patients diagnosed with LC were retrospectively analysed. The study population was divided in a CNV group (showing the documented onset of a CNV) and a n-CNV group (no CNV development during follow-up). LC area was measured using MatLab software after the application of a customized method for LC segmentation on infrared (IR) enface images.
Results
Forty-five (45) patients with a mean follow-up of 4.9 ± 1.5 years were included. LC area at baseline was 2.82 ± 0.54 mm2 and 1.70 ± 0.49 mm2 in CNV (20 patients) and n-CNV group (25 patients) group respectively (p < 0.001). LC area increase was significantly higher in CNV group (p < 0.001). Time to onset of CNV was linearly correlated with both LC area at baseline (p = 0.006) and LC area increase (p < 0.001).
Conclusions
Myopic CNV development is associated with lager LC areas and higher LC area increase during time. Earlier CNV onset is inversely correlated with LC area and LC area increase.
中文翻译:
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AI测漆裂纹扩展与近视脉络膜新生血管发展的相关性
目标
研究首次检测到的漆裂纹 (LC) 的 AI 测量面积与病理性近视患者随访期间脉络膜新生血管 (CNV) 发生率之间的相关性。次要结果是检测 CNV 发作时间与基线 LC 面积和随访期间 LC 面积增加之间的相关性。
方法
回顾性分析了诊断为 LC 的患者的光学相干断层扫描 (OCT) 图像。研究人群分为 CNV 组(显示记录的 CNV 发作)和 n-CNV 组(随访期间未发生 CNV)。在对红外 (IR) 正面图像应用定制的 LC 分割方法后,使用 MatLab 软件测量 LC 面积。
结果
包括四十五 (45) 名平均随访时间为 4.9 ± 1.5 年的患者。CNV(20 名患者)和 n-CNV 组(25 名患者)的基线 LC 面积分别为 2.82 ± 0.54 mm 2和 1.70 ± 0.49 mm 2 ( p < 0.001)。CNV 组的 LC 面积增加明显更高 ( p < 0.001)。CNV 发作时间与基线时的 LC 面积 ( p = 0.006) 和 LC 面积增加 ( p < 0.001)呈线性相关。
结论
近视 CNV 发展与更大的 LC 区域和更高的 LC 区域随时间增加有关。较早的 CNV 发作与 LC 面积和 LC 面积增加呈负相关。