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Intrafibrillar Mineralization and Immunomodulatory for Synergetic Enhancement of Bone Regeneration via Calcium Phosphate Nanocluster Scaffold
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-03-03 , DOI: 10.1002/adhm.202201548 Yanyan Zhou 1 , Zihe Hu 1 , Wenjing Jin 1 , Haiyan Wu 1 , Minghao Zuo 1 , Changyu Shao 1 , Yanhua Lan 1 , Yang Shi 1 , Ruikang Tang 2 , Zhuo Chen 1 , Zhijian Xie 1 , Jue Shi 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-03-03 , DOI: 10.1002/adhm.202201548 Yanyan Zhou 1 , Zihe Hu 1 , Wenjing Jin 1 , Haiyan Wu 1 , Minghao Zuo 1 , Changyu Shao 1 , Yanhua Lan 1 , Yang Shi 1 , Ruikang Tang 2 , Zhuo Chen 1 , Zhijian Xie 1 , Jue Shi 1
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Inspired by the bionic mineralization theory, organic–inorganic composites with hydroxyapatite nanorods orderly arranged along collagen fibrils have attracted extensive attention. Planted with an ideal bone scaffold will contribute greatly to the osteogenic microenvironment; however, it remains challenging to develop a biomimetic scaffold with the ability to promote intrafibrillar mineralization and simultaneous regulation of immune microenvironment in situ. To overcome these challenges, a scaffold containing ultra-small particle size calcium phosphate nanocluster (UsCCP) is prepared, which can enhance bone regeneration through the synergetic effect of intrafibrillar mineralization and immunomodulatory. By efficient infiltration into collagen fibrils, the UsCCP released from the scaffold achieves intrafibrillar mineralization. It also promotes the M2-type polarization of macrophages, leading to an immune microenvironment with both osteogenic and angiogenic potential. The results confirm that the UsCCP scaffold has both intrafibrillar mineralization and immunomodulatory effects, making it a promising candidate for bone regeneration.
中文翻译：
纤维内矿化和免疫调节通过磷酸钙纳米簇支架协同增强骨再生
受仿生矿化理论的启发，羟基磷灰石纳米棒沿胶原纤维有序排列的有机-无机复合材料引起了广泛关注。植入理想的骨支架将极大地促进成骨微环境；然而，开发一种能够促进纤维内矿化并同时原位调节免疫微环境的仿生支架仍然具有挑战性。为了克服这些挑战，制备了一种含有超小粒径磷酸钙纳米团簇 (UsCCP) 的支架，它可以通过纤维内矿化和免疫调节的协同作用增强骨再生。通过有效渗透到胶原纤维中，从支架释放的 UsCCP 实现了纤维内矿化。它还促进巨噬细胞的 M2 型极化，导致具有成骨和血管生成潜力的免疫微环境。结果证实，UsCCP 支架同时具有纤维内矿化和免疫调节作用，使其成为骨再生的有希望的候选者。
更新日期：2023-03-03
中文翻译：
纤维内矿化和免疫调节通过磷酸钙纳米簇支架协同增强骨再生
受仿生矿化理论的启发，羟基磷灰石纳米棒沿胶原纤维有序排列的有机-无机复合材料引起了广泛关注。植入理想的骨支架将极大地促进成骨微环境；然而，开发一种能够促进纤维内矿化并同时原位调节免疫微环境的仿生支架仍然具有挑战性。为了克服这些挑战，制备了一种含有超小粒径磷酸钙纳米团簇 (UsCCP) 的支架，它可以通过纤维内矿化和免疫调节的协同作用增强骨再生。通过有效渗透到胶原纤维中，从支架释放的 UsCCP 实现了纤维内矿化。它还促进巨噬细胞的 M2 型极化，导致具有成骨和血管生成潜力的免疫微环境。结果证实，UsCCP 支架同时具有纤维内矿化和免疫调节作用，使其成为骨再生的有希望的候选者。
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