Abstract

A one pot synthesis of ethyl 1-(1,2-dihydro-2-oxoquinoxalin-3-yl)-1H-pyrazole-4-carboxylate has been developed using the 3-hydrazineylquinoxalin-2(1H)-N-alkylation derivatizes one and ethyl 2-Formyl-3-oxopropionate and further this scaffold to afford the various novel ethyl 1-(4-Alkyl-3-oxo-3,4-dihydroquinoxalin-2-yl)-1H-pyrazole-4-carboxylate derivatives. The developed method is a novel, cost-effective, and industrially viable method. Consequently, the process described is less cumbersome due to the number of reaction stages reduced, the purity of the organic compound produced, and the substantial yield. This novel synthetic route is believed to be the shortest and most efficient of previous synthetic routes. The established route could be facilitated to prepare various key intermediates and active pharmaceutical ingredients.

摘要

使用 3-hydrazineylquinoxalin-2(1 H )- N -烷基化开发了1-(1,2-dihydro-2-oxoquinoxalin-3-yl)-1 H -pyrazole-4-carboxylate 乙酯的一锅法合成衍生化一种和乙基 2-甲酰基-3-氧代丙酸酯，并进一步衍生该支架以提供各种新型乙基 1-(4-Alkyl-3-oxo-3,4-dihydroquinoxalin-2-yl)-1 H-pyrazole-4-carboxylate 衍生物。所开发的方法是一种新颖、具有成本效益且在工业上可行的方法。因此，由于减少了反应阶段的数量、所产生的有机化合物的纯度和可观的收率，所描述的方法不那么繁琐。这种新的合成路线被认为是以前合成路线中最短和最有效的。建立的路线可以促进制备各种关键中间体和活性药物成分。