Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes,Japanese Journal of Ophthalmology

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Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes
Japanese Journal of Ophthalmology ( IF 2.1 ) Pub Date : 2023-03-03 , DOI: 10.1007/s10384-023-00978-9
Naoko Yamada-Okahara ₁ , Akika Kyo ₁ , Kumiko Hirayama ₁ , Manabu Yamamoto ₁ , Takeya Kohno ₁ , Shigeru Honda ₁

Affiliation

Purpose

Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the best clinical practice and the outcomes of these modalities.

Study design

A retrospective interventional study.

Methods

The records of 71 eyes of 68 treatment naïve pCSC cases who underwent PC, SRT, or PDT were reviewed. First, the baseline clinical parameters were evaluated to find significant factors associated with the choice of treatment option. Second, the 3 months’ visual and anatomical outcomes of each modality were assessed.

Results

The PC, SRT, and PDT groups included 7, 22, and 42 eyes, respectively. The leakage pattern in fluorescein angiography (FA) was significantly associated with the choice of treatment (p<0.005). The dry macula ratio at 3 months post-treatment was 29%, 59%, and 81% in the PC, SRT, and PDT groups, respectively, which significantly differed among the groups (p<0.01). The best-corrected visual acuities tended to be improved after the treatments in all groups. Central choroidal thickness (CCT) was significantly decreased in all groups (p<0.05, p<0.01, and p<0.00001, in PC, SRT, and PDT groups, respectively). Logistic regression analysis for dry macula revealed that SRT (p<0.05), PDT (p<0.05), and the changes in CCT (p<0.01)were the significant association factors.

Conclusion

The leakage pattern in FA was associated with the choice of treatment option for pCSC. PDT achieved a significantly higher dry macula ratio than PC, 3 months after the treatment.

中文翻译：

持续性中心性浆液性脉络膜视网膜病变的实用治疗选择以及早期视觉和解剖结果

目的

持续性中心性浆液性脉络膜视网膜病变 (pCSC) 可通过激光光凝术 (PC)、选择性视网膜疗法 (SRT) 或光动力疗法 (PDT) 进行治疗。我们对最佳临床实践中 pCSC 治疗的选择和这些方式的结果进行了回顾性分析。

学习规划

一项回顾性干预研究。

方法

回顾了接受 PC、SRT 或 PDT 的 68 例未经治疗的 pCSC 病例的 71 只眼的记录。首先，评估基线临床参数以找到与治疗方案选择相关的重要因素。其次，评估了每种方式的 3 个月视觉和解剖结果。

结果

PC、SRT 和 PDT 组分别包括 7、22 和 42 只眼。荧光素血管造影 (FA) 中的渗漏模式与治疗选择显着相关 (p<0.005)。PC、SRT 和 PDT 组治疗后 3 个月的干性黄斑比例分别为 29%、59% 和 81%，各组间差异显着 (p<0.01)。各组治疗后最佳矫正视力均有改善趋势。所有组的中央脉络膜厚度 (CCT) 均显着降低（PC、SRT 和 PDT 组分别为 p<0.05、p<0.01 和 p<0.00001）。干性黄斑的 Logistic 回归分析显示 SRT (p<0.05)、PDT (p<0.05) 和 CCT 的变化 (p<0.01) 是显着的相关因素。