基于功能性丝胶水凝胶电极的可降解和生物相容性超级电容器植入物,Advanced Energy Materials

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基于功能性丝胶水凝胶电极的可降解和生物相容性超级电容器植入物
Advanced Energy Materials ( IF 24.4 ) Pub Date : 2023-03-02 , DOI: 10.1002/aenm.202203814
Qiying Lv ₁ , Xiaoye Li ₂ , Xin Tian ₃ , Da‐an Fu ₁ , Huan Liu ₂ , Jia Liu ₁ , Yu Song ₁ , Bo Cai ₁ , Jian Wang ₂ , Qiangfei Su ₂ , Wei Chen ₄ , Meizhen Zou ₂ , Fei Xiao ₃ , Shuai Wang ₃ , Zheng Wang _{1,

5} , Lin Wang _{1,

2}

Affiliation

植入式电源在平衡多种因素方面面临巨大挑战，包括高性能、生物相容性、软组织贴合的机械性能和生物降解性。为了实现这一目标，提出了一种简单可行的方法来制备可植入的水凝胶基超级电容器 (SC)。特别地，多网络导电电极由胺化还原氧化石墨烯和甲基丙烯酸酐共改性丝胶蛋白 (SrMA/A-rGO) 与四臂聚乙二醇琥珀酰亚胺碳酸酯和聚乙二醇丙烯酸酯依次交联原位形成. 导电多网络赋予基于 SrMA/A-rGO 的 SC 植入物等效串联电阻 21 Ω cm ^-2，体积能量密度为 26.0 µW cm ^-2，长期充放电后比电容保持率高（超过76.4%）。串联连接的两个 SC 能够点亮用于体外和体内研究的发光二极管。此外，它们还可以作为直接输出电源，用电刺激停止跳动的心脏重新开始跳动。此外，SC 在体内表现出优异的生物相容性和生物降解性，植入后 2 周的比电容值保持在 30% 以上。因此，这项工作展示了基于 SrMA/A-rGO 的 SC 作为医疗植入物（例如临时起搏器）的能量存储单元的潜力。

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A Degradable and Biocompatible Supercapacitor Implant Based on Functional Sericin Hydrogel Electrode

Implantable power sources face great challenges in balancing multiple factors including high performance, biocompatibility, mechanical properties for soft tissue fit, and biodegradability. Toward this goal, a simple and feasible method is proposed to prepare implantable a hydrogel-based supercapacitor (SC). Specially, a multinetwork conductive electrode is in situ formed by aminated-reduced-graphene-oxide-and-methacrylic-anhydride-comodified sericin (SrMA/A-rGO) sequentially cross-linking with four-arm polyethylene glycol succinimide carbonate and polyethylene glycol acrylate. The conductive multinetwork endows the SrMA/A-rGO-based SC implant an equivalent series resistance of 21 Ω cm⁻², a volumetric energy density of 26.0 µW cm⁻², and a high specific capacitance retention (over 76.4%) after long-term charging/discharging. Two SCs connected in tandem are able to light up a light-emitting diode for both in vitro and in vivo studies. Moreover, they can work as a direct output power source to electrically stimulate a stopped heart to start beating again. Additionally, the SC exhibits superior biocompatibility and biodegradability in vivo, and holds the value of specific capacitance above 30% 2 weeks after implantation. Thus, this work demonstrates the SrMA/A-rGO-based SC's potential to serve as a power storage unit for medical implants (such as a temporary pacemaker).

更新日期：2023-03-02

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