NIR-II semiconducting polymers for in vivo high-resolution imaging and theranostics,Sensors & Diagnostics

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NIR-II semiconducting polymers for in vivo high-resolution imaging and theranostics
Sensors & Diagnostics ( IF 3.5 ) Pub Date : 2023-03-02 , DOI: 10.1039/d2sd00234e
Xiaoying Kang ₁ , Shuai Yin _{1,

2} , Jianwen Song ₁ , Yuan Zhang ₁ , Ji Qi ₁

Affiliation

Precision medicine calls for accurate diagnostic and therapeutic methods that could increase disease sensing and treatment outcome. The second near-infrared (NIR-II, 1000–1700 nm) window has attracted considerable attention because as the light–tissue interaction such as scattering and reflection, absorption and autofluorescence significantly decreases, it enables excellent penetration depth and spatial resolution. Semiconducting polymers (SPs) possess the merits of good stability, easily tunable structures and properties, and potential degradation, holding great potential for NIR-II biomedical applications. In this minireview, we summarize the recent advances in SPs with NIR-II fluorescence emission for precise diagnostics and theranostics. The development and emerging strategies for obtaining high-brightness NIR-II SPs are discussed. NIR-II SPs with other functions including photoacoustic imaging, photothermal therapy, photodynamic therapy and immunotherapy for disease theranostics are illustrated. Biomedical applications such as in vivo high-resolution angiography, brain imaging, and various phototheranostic modalities are also highlighted. This review aims to provide guidance for designing high-performance NIR-II SPs to realize maximized effectiveness of various bio-applications, and it will also provide comprehensive understanding about the chemical structure–photophysical property–biomedical application relationships of organic/polymer phototheranostic materials.

中文翻译：

用于体内高分辨率成像和治疗诊断学的 NIR-II 半导体聚合物

精准医学需要准确的诊断和治疗方法，以提高疾病感知和治疗效果。第二个近红外（NIR-II，1000-1700 nm）窗口引起了相当大的关注，因为随着散射和反射、吸收和自发荧光等光-组织相互作用的显着降低，它具有出色的穿透深度和空间分辨率。半导体聚合物 (SP) 具有稳定性好、结构和性能易于调节以及潜在降解等优点，在 NIR-II 生物医学应用方面具有巨大潜力。在这篇小型综述中，我们总结了用于精确诊断和治疗诊断的具有 NIR-II 荧光发射的 SP 的最新进展。讨论了获得高亮度 NIR-II SP 的发展和新兴策略。NIR-II SP 具有其他功能，包括光声成像、光热疗法、光动力疗法和疾病治疗的免疫疗法。生物医学应用，例如还强调了体内高分辨率血管造影、脑成像和各种光疗模式。本综述旨在为设计高性能 NIR-II SP 以实现各种生物应用的最大有效性提供指导，同时也将提供对有机/聚合物光疗材料的化学结构-光物理性质-生物医学应用关系的全面理解。

更新日期：2023-03-02

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