Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they are structural analogs of purines. Thienopyrimidine derivatives have various biological activities. The current review discusses different synthetic methods for the preparation of heterocyclic thienopyrimidine derivatives. It also highlights the most recent research on the anticancer effects of thienopyrimidines through the inhibition of various enzymes and pathways, which was published within the last 9 years.

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噻吩并嘧啶衍生物作为抗癌剂的最新进展

噻吩并嘧啶衍生物在稠合嘧啶化合物中占有独特的地位。它们在药物化学中很重要并广泛存在，因为它们是嘌呤的结构类似物。噻吩并嘧啶衍生物具有多种生物活性。本综述讨论了制备杂环噻吩并嘧啶衍生物的不同合成方法。它还强调了最近 9 年内发表的关于噻吩并嘧啶通过抑制各种酶和途径的抗癌作用的最新研究。

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