Salt-Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti-Multiple Encrustations in Urological Devices,Advanced Healthcare Materials

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Salt-Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti-Multiple Encrustations in Urological Devices
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-02-28 , DOI: 10.1002/adhm.202203328
Huan Yu _{1,

2} , Hengchong Shi _{1,

2} , Ming Zhu ₃ , Xu Zhang ₂ , Lei Wang ₂ , Gongwei Tian ₄ , Lingjie Song ₂ , Shifang Luan _{1,

2} , Dianpeng Qi ₄ , Xiaodong Chen _{3,

5}

Affiliation

Bacterial infections and multiple encrustations are life-threatening complications in patients implanted with urological devices. Limited by time-consuming procedures and substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, is reported the design of a salt-triggered chondroitin sulfate complex (CS/Si-N⁺) coating with adaptive dissociation, which realizes the dual functions of antibacterial and anti-multiple encrustations in urological devices with arbitrary shapes. The existence of covalent interactions between the complex and the interface ensures the formation of a robust coating, especially in harsh environments. Benefiting from the adaptive dissociation of the ion pairs in the CS/Si-N⁺ coating in urine electrolytes, the exposed ion groups and enhanced hydrophilicity are more conducive to the inhibition of bacterial infection and multiple encrustations simultaneously. The coating exhibits broad-spectrum bactericidal effects. As a proof of concept, in a simulated metabolic encrustation model, the coating exhibits significant advantages in resisting calcium oxalate encrustation, with a reduction in the calcium content by over 90%. In addition, this non-leachable all-in-one coating shows good biocompatibility in a pig in vivo model. Such a coating strategy is expected to be a practical approach for preventing urological medical device-related complications.

中文翻译：

具有抗菌和抗多结垢双重功效的盐触发自适应解离涂层在泌尿外科器械中的应用

细菌感染和多发结痂是植入泌尿装置的患者危及生命的并发症。受耗时的过程和基质依赖性的限制，很难同时预防上述并发症。本文报道了一种具有适应性解离的盐触发硫酸软骨素复合物（CS/Si-N ⁺）涂层的设计，该涂层在任意形状的泌尿器械中实现了抗菌和抗多结垢的双重功能。复合物与界面之间共价相互作用的存在确保了坚固涂层的形成，尤其是在恶劣的环境中。^{受益于 CS/Si-N +}中离子对的自适应解离涂层在尿液电解质中，暴露的离子基团和增强的亲水性更有利于同时抑制细菌感染和多重结垢。该涂层具有广谱杀菌作用。作为概念验证，在模拟代谢结垢模型中，该涂层在抵抗草酸钙结垢方面表现出显着的优势，钙含量降低了 90% 以上。此外，这种不可浸出的一体化涂层在猪体内模型中表现出良好的生物相容性。这种涂层策略有望成为预防泌尿医疗器械相关并发症的实用方法。

更新日期：2023-02-28

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