Molecules containing triazolopyrimidine core showed diverse biological activities, including anti-Alzheimer's, anti-diabetes, anti-cancer, anti-microbial, anti-tuberculosis, anti-viral, anti-malarial, anti-inflammatory, anti-parkinsonism, and anti-glaucoma activities. Triazolopyrimidines have 8 isomeric structures, including the most stable 1,2,4-triazolo[1,5- a] pyrimidine ones. Triazolopyrimidines were obtained by using various chemical reactions, including a) 1,2,4-triazole nucleus annulation to pyrimidine, b) pyrimidines annulation to 1,2,4-triazole structure, c) 1,2,4-triazolo[l,5-a] pyrimidines rearrangement, and d) pyrimidotetrazine rearrangement. This review discusses synthetic methods, recent pharmacological actions and drug delivery perspectives of triazolopyrimidines.

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三唑并嘧啶衍生物：合成、生物活性和药物递送 Asp 最新进展的最新综述

含有三唑并嘧啶核心的分子表现出多种生物活性，包括抗阿尔茨海默病、抗糖尿病、抗癌、抗菌、抗结核、抗病毒、抗疟疾、抗炎、抗帕金森病和抗青光眼活动。三唑并嘧啶有8种异构体结构，包括最稳定的1,2,4-三唑并[1,5-a]嘧啶结构。三唑并嘧啶通过各种化学反应获得，包括a) 1,2,4-三唑核环化为嘧啶，b) 嘧啶环化为1,2,4-三唑结构，c) 1,2,4-三唑[l, 5-a]嘧啶重排，和d)嘧啶四嗪重排。本综述讨论了三唑并嘧啶类药物的合成方法、最新药理作用和药物递送前景。