槲皮素和生姜对砷酸钠致大鼠神经毒性的保护作用,Food Science & Nutrition

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槲皮素和生姜对砷酸钠致大鼠神经毒性的保护作用
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2023-02-28 , DOI: 10.1002/fsn3.3278
Rasia Yousuf ₁ , Pawan Kumar Verma ₁ , Priyanka Sharma ₁ , Shilpa Sood ₂ , Muhammad A Bhatti ₃ , Zuhaib F Bhat ₄

Affiliation

该研究旨在确定槲皮素和生姜(ZO) 对雄性 Wistar 大鼠砷酸钠诱导的神经毒性的改善潜力。三十只成年动物被随机分配到五组（n = 6). I 组作为对照组，II 组和 IV 组用 ZO [300 mg/kg，PO（口服）/天]治疗，V 组动物给予槲皮素（50 mg/kg，PO/天）18 天。第 III、IV 和 V 组从第 15 天开始连续 4 天注射砷酸钠（20 mg/kg，腹腔注射/天）。施用砷酸钠导致总抗氧化状态、总硫醇、超氧化物歧化酶显着降低与对照组相比，动物脑组织中过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和芳基酯酶。此外，观察到丙二醛、高级氧化蛋白产物和血浆一氧化氮水平显着增加，表明氧化应激介导的神经元损伤。然而，这些砷引起的改变在治疗组中被槲皮素或 ZO 显着逆转，表明它们具有改善潜力。脑组织的组织病理学检查进一步证实了这些积极作用，揭示了用槲皮素和 ZO 预处理的样品中严重神经元损伤、海绵化和神经胶质增生的抑制。我们的结果表明，在饮食中加入富含 ZO 和槲皮素的食物有助于预防食物链和地下水中砷含量升高地区的神经毒性作用。

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Neuroprotective effect of quercetin and Zingiber officinale on sodium arsenate-induced neurotoxicity in rats

The study was aimed at determining the ameliorative potential of quercetin and Zingiber officinale (ZO) against sodium arsenate-induced neurotoxicity in male Wistar rats. Thirty adult animals were randomly allocated to five groups (n = 6). Group I served as control, groups II and IV were treated with ZO [300 mg/kg, PO (per os)/day], and group V animals were administered quercetin (50 mg/kg, PO/day) for 18 days. Groups III, IV, and V were injected with sodium arsenate (20 mg/kg, intraperitoneally/day) for 4 days starting from day 15. The administration of sodium arsenate resulted in a significant decrease in total antioxidant status, total thiols, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and aryl esterase in brain tissue of the animals compared with the control group. In addition, a significant increase was observed in malondialdehyde, advanced oxidation protein product and plasma nitric oxide levels, indicating oxidative stress-mediated neuronal damage. However, these arsenic-induced alterations were significantly reversed by quercetin or ZO in the treatment groups, indicating their ameliorative potential. These positive effects were further confirmed by histopathological examination of brain tissue revealing the suppression of severe neuronal injury, spongiosis and gliosis in the samples pretreated with quercetin and ZO. Our results suggest that inclusion of ZO and quercetin-rich foods in the diet can help in preventing the neurotoxic effects in areas with elevated levels of arsenic in food chain and ground water.

更新日期：2023-02-28

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