Synthesis, Subcellular Localization and Anticancer Mechanism Studies of Unsymmetrical Iridium(III) Complexes,European Journal of Inorganic Chemistry

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Synthesis, Subcellular Localization and Anticancer Mechanism Studies of Unsymmetrical Iridium(III) Complexes
European Journal of Inorganic Chemistry ( IF 2.2 ) Pub Date : 2023-02-28 , DOI: 10.1002/ejic.202300001
Lina Xie ₁ , Le Shi ₂ , Kai Xiong ₃ , Ruilin Guan ₃ , Yu Chen ₃ , Jiangang Long ₂ , Liangnian Ji ₃ , Hui Chao ₄

Affiliation

Two Ir(III) complexes with similar structures exhibited different anticancer mechanisms. Ir1 selectively accumulated in mitochondria and induced mitochondrial-mediated apoptosis in A549R cells. Ir2 translocated from mitochondria to the nucleus and induced necroptosis in A549R cells.

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