Polydopamine-Coated Radiolabeled Microspheres for Combinatorial Radioembolization and Photothermal Cancer Therapy,ACS Applied Materials & Interfaces

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Polydopamine-Coated Radiolabeled Microspheres for Combinatorial Radioembolization and Photothermal Cancer Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-02-28 , DOI: 10.1021/acsami.2c19829
Manran Wu ₁ , Lei Zhang ₂ , Kexin Shi ₁ , Dongxu Zhao ₂ , Weipeng Yong ₁ , Lingling Yin ₁ , Ruizhe Huang ₁ , Guanglin Wang ₁ , Gang Huang ₃ , Mingyuan Gao ₁

Affiliation

Transarterial radioembolization (TARE) is a local radionuclide therapy and is successfully used in hepatocellular carcinoma (HCC) treatment. Radioactive microspheres have been widely studied for TARE. Preparation of ideal radioactive microspheres is significant for clinical research and patient treatment. In this study, we have designed a novel multifunctional microsphere, i.e., polydopamine (PDA)-coated ¹⁷⁷Lu-radiolabeled silica microspheres (MS) denoted as ¹⁷⁷Lu-MS@PDA, which can be used for TARE and photothermal therapy (PTT). The radiostability of ¹⁷⁷Lu-MS@PDA was significantly improved by coating ¹⁷⁷Lu-MS with PDA. In addition, the coating of PDA makes microspheres have excellent photothermal performance. MicroSPECT/CT images showed that ¹⁷⁷Lu-MS@PDA was accurately embolized and remained in the tumor during the observation time. At the time, it also showed that ¹⁷⁷Lu-MS@PDA was very stable in vivo. Furthermore, the anti-tumor results demonstrated that TARE combined with PTT of ¹⁷⁷Lu-MS@PDA can significantly inhibit tumor growth without obvious side effects. ¹⁷⁷Lu-MS@PDA holds great potential as a promising radioactive microsphere for HCC.

中文翻译：

用于联合放射栓塞和光热癌症治疗的聚多巴胺涂层放射性标记微球

经动脉放射栓塞术 (TARE) 是一种局部放射性核素疗法，已成功用于肝细胞癌 (HCC) 的治疗。放射性微球已被广泛研究用于 TARE。制备理想的放射性微球对于临床研究和患者治疗具有重要意义。在这项研究中，我们设计了一种新型多功能微球，即聚多巴胺 (PDA) 包被的¹⁷⁷ Lu-放射性标记二氧化硅微球 (MS)，表示为¹⁷⁷ Lu-MS@PDA，可用于 TARE 和光热疗法 (PTT) . ¹⁷⁷ Lu-MS@PDA的辐射稳定性通过涂覆¹⁷⁷显着提高带 PDA 的 Lu-MS。此外，PDA的包覆使得微球具有优异的光热性能。MicroSPECT/CT图像显示，¹⁷⁷ Lu-MS@PDA在观察时间内被准确栓塞并留在肿瘤内。当时也表明¹⁷⁷ Lu-MS@PDA 在体内非常稳定。此外，抗肿瘤结果表明，TARE联合¹⁷⁷ Lu-MS@PDA的PTT可显着抑制肿瘤生长，且无明显副作用。¹⁷⁷ Lu-MS@PDA 具有作为 HCC 有前途的放射性微球的巨大潜力。

更新日期：2023-02-28

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