二维 Al-TCPP MOF 纳米片的简便合成用于有效的声动力癌症治疗,Materials Chemistry Frontiers

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二维 Al-TCPP MOF 纳米片的简便合成用于有效的声动力癌症治疗
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2023-03-01 , DOI: 10.1039/d2qm01333a
Zhan Zhou ₁ , Tao Wang ₂ , Tingting Hu ₂ , Chunhua Cheng ₁ , Shilong Yu ₃ , Hai Li ₃ , Shuyan Liu ₄ , Lufang Ma ₁ , Meiting Zhao ₅ , Ruizheng Liang ₂ , Chaoliang Tan _{6,

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Affiliation

近年来，二维 (2D) 金属有机骨架 (MOF) 纳米片作为癌症治疗的诊断和治疗试剂得到了广泛探索，包括光动力疗法、化学动力疗法、放射疗法和催化疗法，因为它们具有吸引人的物理化学特性. 在此，我们报告了二维 Al-TCPP（TCPP：四（4-羧基苯基）卟啉）MOF 纳米片的首次制备，用作声动力癌症治疗的有效声敏剂，通过简单的溶剂热合成方法无需任何表面活性剂。2D Al-TCPP 纳米片的尺寸为 160-200 nm，厚度为 18.4-26.5 nm，通过改变水与N的比例合成，N-二甲基甲酰胺。有趣的是，其他有机溶剂，如二甲基乙酰胺、二甲基亚砜和N-甲基-2-吡咯烷酮，也可以用作轻松合成二维 Al-TCPP 纳米片的共溶剂。令人鼓舞的是，Al-TCPP 纳米片在超声处理下产生的活性氧（即单线态氧（¹ O ₂）和羟基自由基（˙OH））比游离 TCPP 分子高得多，这表明将 TCPP 分子嵌入到2D Al-TCPP 纳米片可以显着增强声动力学癌症治疗活性。体外和体内_结果证明，经聚乙二醇修饰后的Al-TCPP纳米片可作为声敏剂用于高效的声动力疗法，杀灭癌细胞，消除恶性肿瘤。

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Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy

Two-dimensional (2D) metal–organic framework (MOF) nanosheets have been widely explored in recent years as diagnostic and therapeutic reagents for cancer therapies, including photodynamic therapy, chemodynamic therapy, radiation therapy, and catalytic therapy, because of their appealing physicochemical properties. Herein, we report the first preparation of 2D Al-TCPP (TCPP: tetrakis(4-carboxyphenyl)porphyrin) MOF nanosheets, for use as an effective sonosensitizer for sonodynamic cancer therapy, via a simple solvothermal synthesis method without the need for any surfactants. The 2D Al-TCPP nanosheets have a size of 160–200 nm and a thickness of 18.4–26.5 nm and were synthesized by changing the ratio of water to N,N-dimethylformamide. Interestingly, other organic solvents, such as dimethylacetamide, dimethyl sulfoxide, and N-methyl-2-pyrrolidone, can be also used as the co-solvent for the facile synthesis of the 2D Al-TCPP nanosheets. Promisingly, the Al-TCPP nanosheets generate a much higher yield of reactive oxygen species (i.e., singlet oxygen (¹O₂) and hydroxyl radical (˙OH)) under ultrasound treatment than free TCPP molecules, suggesting that embedding the TCPP molecules in the 2D Al-TCPP nanosheets could significantly enhance the sonodynamic cancer therapeutic activity. Both the in vitro and in vivo results prove that, after modification with polyethylene glycol, the Al-TCPP nanosheets can be used as a sonosensitizer for efficient sonodynamic therapy to kill cancer cells and eliminate malignant tumors.

更新日期：2023-03-01

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