膨胀诱导的机械坚韧淀粉琼脂基水凝胶作为伤口敷料应用的控制释放药物载体,Journal of Materials Chemistry B

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膨胀诱导的机械坚韧淀粉琼脂基水凝胶作为伤口敷料应用的控制释放药物载体
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-02-28 , DOI: 10.1039/d2tb02775e
Dimpee Sarmah ₁ , Munmi Borah ₂ , Manabendra Mandal ₂ , Niranjan Karak ₁

Affiliation

近年来，多糖基水凝胶由于其固有的生物降解性、生物相容性和无毒性而受到越来越多的关注。使用多糖合成水凝胶的可行性取决于它们显着的机械强度和细胞相容性，这是实际应用，特别是生物医学用途所必需的。在这项研究中，我们展示了一种简便的合成路线，用于使用淀粉和琼脂等多糖构建机械坚韧、生物相容且可生物降解的水凝胶。使用环氧氯丙烷作为交联剂合成了无单体水凝胶，机械强度达到 9.49 ± 1.29–6.16 ± 0.37 MPa。将琼脂引入水凝胶导致琼脂剂量依赖性溶胀诱导的机械强度。而且，除了令人难以置信的机械强度外，这种水凝胶还对人类胚胎肾细胞表现出显着的细胞活力。此外，该水凝胶对盐酸环丙沙星水合物等抗菌药物具有良好的包封效果，并具有持续控释能力。观察包封药物的抗菌活性金黄色葡萄球菌和枯草杆菌菌株。因此，所研究的载有药物的水凝胶表现出所有所需的品质，可用作伤口敷料应用中的有前途的候选者。

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Swelling induced mechanically tough starch–agar based hydrogel as a control release drug vehicle for wound dressing applications

In recent years, polysaccharide-based hydrogels have received increased attention due to their inherent biodegradability, biocompatibility, and non-toxicity. The feasibility of using polysaccharides for the synthesis of hydrogels is dependent on their noteworthy mechanical strength and cell compatibility, which are required for practical applications, especially for biomedical uses. In this study, we demonstrate a facile synthetic route for the construction of a mechanically tough, biocompatible, and biodegradable hydrogel using polysaccharides such as starch and agar. A synthetic monomer-free hydrogel was synthesized using epichlorohydrin as a cross-linker, and a mechanical strength of 9.49 ± 1.29–6.16 ± 0.37 MPa was achieved. The introduction of agar into the hydrogel resulted in agar dose-dependent swelling-induced mechanical strength. Moreover, along with incredible mechanical strength, the hydrogel also exhibited prominent cell viability against human embryonic kidney cells. In addition, the hydrogel showed good encapsulation efficiency for antibacterial drugs like ciprofloxacin hydrochloride hydrate, with controlled releasing ability over a sustained period. The antibacterial activity of the encapsulated drug was observed against Staphylococcus aureus and Bacillus subtilis bacterial strains. Thus, the studied hydrogel with loaded drug exhibited all the required qualities to be utilized as a promising candidate in wound dressing applications.

更新日期：2023-02-28

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