Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin
Heliyon ( IF 3.4 ) Pub Date : 2023-02-14 , DOI: 10.1016/j.heliyon.2023.e13705
Bo Yu 1, 2 , Ruiping Shi 1 , Chunlai Liu 1 , Zelong Liu 1 , Peihang Shen 1 , Jianglei Hu 1 , Fengwei Shi 1
Heliyon ( IF 3.4 ) Pub Date : 2023-02-14 , DOI: 10.1016/j.heliyon.2023.e13705
Bo Yu 1, 2 , Ruiping Shi 1 , Chunlai Liu 1 , Zelong Liu 1 , Peihang Shen 1 , Jianglei Hu 1 , Fengwei Shi 1
Affiliation
![]() |
This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, respectively. The drug-loaded precursor NH2 -SBA-16@IMC was prepared by solution diffusion adsorption. Finally, the pH-responsive drug-loaded composites NH2 -SBA-16@IMC@GA were synthesized by wrapping the NH2 -SBA-16@IMC with a condensation polymer of gelatin and glutaraldehyde. The composition and structure of the drug-loaded composites were characterized by FT-IR, XRD, TG, SEM, TEM, and N2 adsorption-desorption. The in vitro simulated release performance of the drug-loaded composites was investigated at 37 °C under three pH conditions. The results show that the NH2 -SBA-16@IMC@GA can be released in response to specific pH environment, which can effectively control the release speed of the indomethacin.
中文翻译:
用于吲哚美辛缓释的 pH 响应明胶聚合物涂层二氧化硅基介孔复合材料
本文制备了 pH 响应型载药介孔二氧化硅复合材料。以三维笼状二氧化硅 (SBA-16) 为载体,3-氨基丙基三甲氧基硅烷 (APTMS) 为硅烷偶联剂,吲哚美辛 (IMC) 为负载药物,制备了这些复合材料。通过溶液扩散吸附制备载药前体 NH2-SBA-16@IMC。最后,用明胶和戊二醛的缩合聚合物包裹 NH2-SBA-16@IMC 合成了 pH 响应性载药复合材料 NH2-SBA-16@IMC@GA。通过 FT-IR、XRD、TG、SEM、TEM 和 N2 吸附-脱附对载药复合材料的组成和结构进行了表征。在 37 °C 和 3 种 pH 条件下研究了载药复合材料的体外模拟释放性能。结果表明,NH2-SBA-16@IMC@GA 可响应特定 pH 环境释放,可有效控制吲哚美辛的释放速度。
更新日期:2023-02-14
中文翻译:

用于吲哚美辛缓释的 pH 响应明胶聚合物涂层二氧化硅基介孔复合材料
本文制备了 pH 响应型载药介孔二氧化硅复合材料。以三维笼状二氧化硅 (SBA-16) 为载体,3-氨基丙基三甲氧基硅烷 (APTMS) 为硅烷偶联剂,吲哚美辛 (IMC) 为负载药物,制备了这些复合材料。通过溶液扩散吸附制备载药前体 NH2-SBA-16@IMC。最后,用明胶和戊二醛的缩合聚合物包裹 NH2-SBA-16@IMC 合成了 pH 响应性载药复合材料 NH2-SBA-16@IMC@GA。通过 FT-IR、XRD、TG、SEM、TEM 和 N2 吸附-脱附对载药复合材料的组成和结构进行了表征。在 37 °C 和 3 种 pH 条件下研究了载药复合材料的体外模拟释放性能。结果表明,NH2-SBA-16@IMC@GA 可响应特定 pH 环境释放,可有效控制吲哚美辛的释放速度。