用于肿瘤特异性 NIR-II 荧光成像和协同 NIR-II 光热-化学动力学治疗的可激活光疗纳米平台,Small

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用于肿瘤特异性 NIR-II 荧光成像和协同 NIR-II 光热-化学动力学治疗的可激活光疗纳米平台
Small ( IF 13.0 ) Pub Date : 2023-02-28 , DOI: 10.1002/smll.202206053
Yeneng Dai _{1,

2,

3} , Fan Zhang ₁ , Kai Chen ₁ , Zhiquan Sun ₁ , Zhihang Wang ₁ , Yuwen Xue ₁ , Meixing Li ₁ , Quli Fan ₁ , Qingming Shen ₁ , Qi Zhao _{2,

3}

Affiliation

第二个近红外窗口 (NIR-II) 中的光疗已被证明有望用于精确的癌症诊疗。然而，无响应和“始终在线”的成像模式缺乏选择性，导致诊断特异性差。在此，基于 Förster 共振能量转移 (FRET) 原理设计了一种肿瘤微环境 (TME) 激活的 NIR-II 光疗纳米平台 (Ag _{2 S-Fe(III)-DBZ Pdots, AFD NPs)。}AFD NPs 是通过 Ag ₂ S QDs（NIR-II 荧光探针）和超小半导体聚合物点（DBZ Pdots，NIR-II 荧光猝灭剂）利用 Fe(III) 作为配位节点进行自组装而制成的。在正常组织中，由于 Ag _{2之间的 FRET，AFD NPs 保持在“关闭”状态}S QD 和 DBZ Pdots。然而，AFD NPs 的 NIR-II 荧光信号可以被肿瘤组织中过表达的 GSH 快速“开启”，从而实现优异的肿瘤与正常组织 (T/NT) 信号比。此外，释放的 Pdots 和还原的 Fe(II) 离子分别提供 NIR-II 光热疗法 (PTT) 和化学动力学疗法 (CDT)。GSH 耗竭和 NIR-II PTT 效应进一步加剧了 CDT 介导的对肿瘤的氧化损伤，实现了协同抗肿瘤治疗效果。该工作为开发 TME 激活的 NIR-II 光疗纳米探针提供了一种有前途的策略。

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An Activatable Phototheranostic Nanoplatform for Tumor Specific NIR-II Fluorescence Imaging and Synergistic NIR-II Photothermal-Chemodynamic Therapy

The phototheranostics in the second near-infrared window (NIR-II) have proven to be promising for the precise cancer theranostics. However, the non-responsive and “always on” imaging mode lacks the selectivity, leading to the poor diagnosis specificity. Herein, a tumor microenvironment (TME) activated NIR-II phototheranostic nanoplatform (Ag₂S-Fe(III)-DBZ Pdots, AFD NPs) is designed based on the principle of Förster resonance energy transfer (FRET). The AFD NPs are fabricated through self-assembly of Ag₂S QDs (NIR-II fluorescence probe) and ultra-small semiconductor polymer dots (DBZ Pdots, NIR-II fluorescence quencher) utilizing Fe(III) as coordination nodes. In normal tissues, the AFD NPs maintain in “off” state, due to the FRET between Ag₂S QDs and DBZ Pdots. However, the NIR-II fluorescence signal of AFD NPs can be rapidly “turn on” by the overexpressed GSH in tumor tissues, achieving a superior tumor-to-normal tissue (T/NT) signal ratio. Moreover, the released Pdots and reduced Fe(II) ions provide NIR-II photothermal therapy (PTT) and chemodynamic therapy (CDT), respectively. The GSH depletion and NIR-II PTT effect further aggravate CDT mediated oxidative damage toward tumors, achieving the synergistic anti-tumor therapeutic effect. The work provides a promising strategy for the development of TME activated NIR-II phototheranostic nanoprobes.

更新日期：2023-02-28

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