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Photoallosteric Polymersomes toward On-Demand Drug Delivery and Multimodal Cancer Immunotherapy
Advanced Materials ( IF 27.4 ) Pub Date : 2023-02-28 , DOI: 10.1002/adma.202210986 Yi Zheng 1 , Yang Liu 1 , Zhongchao Wu 1 , Chuan Peng 1 , Zuojie Wang 1 , Jingyue Yan 1 , Yue Yan 1 , Zifen Li 1 , Congcong Liu 1 , Jianxin Xue 2 , Hong Tan 1 , Qiang Fu 1 , Mingming Ding 1
Advanced Materials ( IF 27.4 ) Pub Date : 2023-02-28 , DOI: 10.1002/adma.202210986 Yi Zheng 1 , Yang Liu 1 , Zhongchao Wu 1 , Chuan Peng 1 , Zuojie Wang 1 , Jingyue Yan 1 , Yue Yan 1 , Zifen Li 1 , Congcong Liu 1 , Jianxin Xue 2 , Hong Tan 1 , Qiang Fu 1 , Mingming Ding 1
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Allosteric transitions can modulate the self-assembly and biological function of proteins. It remains, however, tremendously challenging to design synthetic allosteric polymeric assemblies with spatiotemporally switchable hierarchical structures and functionalities. Here, a photoallosteric polymersome is constructed that undergoes a rapid conformational transition from β-sheet to α-helix upon exposure to near-infrared light irradiation. In addition to improving nanoparticle cell penetration and lysosome escape, photoinduced allosteric behavior reconstructs the vesicular membrane structure, which stimulates the release of hydrophilic cytolytic peptide melittin and hydrophobic kinase inhibitor sorafenib. Combining on-demand delivery of multiple therapeutics with phototherapy results in apoptosis and immunogenic death of tumor cells, remold the immune microenvironment and achieve an excellent synergistic anticancer efficacy in vivo without tumor recurrence and metastasis. Such a light-modulated allosteric transition in non-photosensitive polymers provides new insight into the development of smart nanomaterials for biosensing and drug delivery applications.
中文翻译：
用于按需药物递送和多模式癌症免疫治疗的光变构聚合物囊泡
变构转变可以调节蛋白质的自组装和生物学功能。然而，设计具有时空可切换的层次结构和功能的合成变构聚合物组件仍然具有巨大的挑战性。在这里，构建了一个光变构聚合物囊泡，它在暴露于近红外光照射时会经历从 β-折叠到 α-螺旋的快速构象转变。除了改善纳米颗粒细胞渗透和溶酶体逃逸外，光诱导的变构行为还可以重建囊泡膜结构，从而刺激亲水性溶细胞肽蜂毒肽和疏水性激酶抑制剂索拉非尼的释放。将多种疗法的按需递送与光疗相结合，导致肿瘤细胞的凋亡和免疫原性死亡，重塑免疫微环境，在体内实现优异的协同抗癌功效，无肿瘤复发和转移。非光敏聚合物中的这种光调制变构转变为开发用于生物传感和药物输送应用的智能纳米材料提供了新的见解。
更新日期：2023-02-28
中文翻译：
用于按需药物递送和多模式癌症免疫治疗的光变构聚合物囊泡
变构转变可以调节蛋白质的自组装和生物学功能。然而，设计具有时空可切换的层次结构和功能的合成变构聚合物组件仍然具有巨大的挑战性。在这里，构建了一个光变构聚合物囊泡，它在暴露于近红外光照射时会经历从 β-折叠到 α-螺旋的快速构象转变。除了改善纳米颗粒细胞渗透和溶酶体逃逸外，光诱导的变构行为还可以重建囊泡膜结构，从而刺激亲水性溶细胞肽蜂毒肽和疏水性激酶抑制剂索拉非尼的释放。将多种疗法的按需递送与光疗相结合，导致肿瘤细胞的凋亡和免疫原性死亡，重塑免疫微环境，在体内实现优异的协同抗癌功效，无肿瘤复发和转移。非光敏聚合物中的这种光调制变构转变为开发用于生物传感和药物输送应用的智能纳米材料提供了新的见解。
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