用于皮肤保护和修复的坚固多酚水凝胶的原位制备,Chemistry of Materials

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用于皮肤保护和修复的坚固多酚水凝胶的原位制备
Chemistry of Materials ( IF 7.2 ) Pub Date : 2023-02-27 , DOI: 10.1021/acs.chemmater.3c00159
Huan Cao ₁ , Jinyao Zhu ₁ , Jianhua Zhang ₁ , Lei Yang ₁ , Xutong Guo ₁ , Rong Tian ₁ , Haoxing Wu ₂ , Yiwen Li ₁ , Zhipeng Gu _{1,

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Affiliation

坚固耐用的多功能多酚水凝胶因其在调节细胞生物学方面的各种迷人特性而被公认为有前途的生物材料候选者。然而，这些水凝胶的构建通常需要多步制造和复杂的凝胶化过程。典型的酚醛缩合是工业树脂结构的表面和原位反应；然而，其在水凝胶制备中的应用鲜有报道。在这项研究中，我们报告了该策略的可行性和模块化原位使用天然多酚（提取物）和甲醛制造各种坚固的多功能天然多酚水凝胶。物理化学表征结果表明，多酚分子的化学结构（如酚羟基）在凝胶化过程后可以得到很好的保持，从而使所制备的水凝胶继承了多酚分子的优点，如良好的紫外线屏蔽、自由基清除、体外数据证明的抗菌性能等。体外和体内_细胞和动物结果进一步证实，所制备的水凝胶能够发挥皮肤保护和修复作用，如紫外线防护和伤口愈合模型所示。总的来说，这种策略可以让天然多酚作为结构和功能合成子，形成更多类型的坚固水凝胶，用于广泛的生物医学应用。

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In Situ Fabrication of Robust Polyphenolic Hydrogels for Skin Protection and Repair

Robust and multifunctional polyphenolic hydrogels have been well acknowledged as promising biomaterial candidates due to their various fascinating properties in regulating cell biology. However, the construction of these hydrogels commonly needs multistep fabrication and a sophisticated gelation process. The typical phenol-aldehyde condensation is a facial and in situ reaction for industrial resin construction; however, its application in hydrogel fabrication is seldom reported. In this study, we reported the feasibility and modularity of this strategy for in situ fabricating various kinds of robust and multifunctional natural polyphenolic hydrogels using natural polyphenol (extracts) and formaldehyde. The physicochemical characterization results demonstrated that the chemical structure (e.g., phenolic hydroxyl groups) of polyphenol molecules could be well maintained after the gelation process, allowing as-prepared hydrogels to inherit the merits of polyphenol molecules, such as good UV shielding, radical scavenging, antibacterial properties, and so forth, as demonstrated by in vitro data. The in vitro and in vivo cellular and animal results further confirmed that the as-prepared hydrogels were able to perform a skin protection and repair role, as demonstrated in UV protection and wound healing models. Collectively, this strategy could allow natural polyphenols as both structural and functional synthons toward more types of robust hydrogels for a wide range of biomedical applications.

更新日期：2023-02-27

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