Chiral Allene-Containing Phosphines in Asymmetric Catalysis,Journal of the American Chemical Society

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Chiral Allene-Containing Phosphines in Asymmetric Catalysis
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2011-11-16 , DOI: 10.1021/ja207748r
Feng Cai ₁ , Xiaotao Pu , Xiangbing Qi , Vincent Lynch , Akella Radha , Joseph M Ready

Affiliation

We demonstrate that allenes, chiral 1,2-dienes, appended with basic functionality can serve as ligands for transition metals. We describe an allene-containing bisphosphine that, when coordinated to Rh(I), promotes the asymmetric addition of arylboronic acids to α-keto esters with high enantioselectivity. Solution and solid-state structural analysis reveals that one olefin of the allene can coordinate to transition metals, generating bi- and tridentate ligands.

中文翻译：

不对称催化中的手性丙二烯膦

我们证明附加有基本官能团的丙二烯、手性 1,2-二烯可以作为过渡金属的配体。我们描述了一种含丙二烯的双膦，当与 Rh(I) 配位时，可促进芳基硼酸以高对映选择性不对称加成到 α-酮酯上。溶液和固态结构分析表明，丙二烯的一种烯烃可以与过渡金属配位，产生双齿和三齿配体。

更新日期：2011-11-16

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