Multienzyme-Like Nanozymes: Regulation, Rational Design, and Application,Advanced Materials

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Multienzyme-Like Nanozymes: Regulation, Rational Design, and Application
Advanced Materials ( IF 27.4 ) Pub Date : 2023-02-25 , DOI: 10.1002/adma.202211210
Jingyi Sheng ₁ , Yuehuang Wu ₂ , He Ding ₁ , Kaizheng Feng ₁ , Yan Shen ₃ , Yu Zhang ₁ , Ning Gu _{1,

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Affiliation

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years and hold huge potential to be applied in diverse fields, especially for biosensing and therapeutics. Compared to single enzyme-like nanozymes, multienzymic nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, and environmentally responsive selectivity. Nevertheless, along with these merits, the catalytic mechanism and rational design of multienzymic nanozymes are more complicated and elusive as compared to single-enzymic nanozymes. In this review, the multienzymic nanozymes classification scheme based on the numbers/types of activities, the internal and external factors regulating the multienzymatic activities, the rational design based on chemical, biomimetic, and computer-aided strategies, and recent progress in applications attributed to the advantages of multicatalytic activities are systematically discussed. Finally, current challenges and future perspectives regarding the development and application of multienzymatic nanozymes are suggested. This review aims to deepen the understanding and inspire the research in multienzymic nanozymes to a greater extent.

中文翻译：

类多酶纳米酶：调控、合理设计和应用

具有一种以上酶样活性的纳米材料被称为多酶纳米酶，近年来它们受到越来越多的关注，并且在不同领域，特别是生物传感和治疗领域具有巨大的应用潜力。与单酶类纳米酶相比，多酶纳米酶具有多种独特的优势，包括协同效应、级联反应和环境响应选择性。然而，除了这些优点之外，多酶纳米酶的催化机制和合理设计比单酶纳米酶更加复杂和难以捉摸。本文综述了基于活性数量/类型的多酶纳米酶分类方案、调节多酶活性的内部和外部因素、基于化学、仿生和计算机辅助策略的合理设计，以及最近的应用进展系统地讨论了多催化活性的优点。最后，提出了多酶纳米酶的开发和应用当前面临的挑战和未来的前景。本综述旨在更大程度地加深对多酶纳米酶的认识并启发其研究。

更新日期：2023-02-25

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