The proton exchange membrane water electrolyzer (PEMWE) has attracted significant attention as a promising technology for large-scale hydrogen production. However, the challenge in developing stable and active catalysts for acidic oxygen evolution reaction (OER) restricts the overall water splitting efficiency. Recently, metal–organic framework (MOF)-based materials have been widely explored as electrocatalysts for acidic OER due to their intrinsically porous structures and excellent tunability. In this review article, the acidic OER mechanism and advanced strategies for designing efficient MOF-based acidic OER electrocatalysts are highlighted. Finally, the challenges and perspectives for the exploration of robust MOF-based OER electrocatalysts in acidic media are discussed.

质子交换膜水电解槽（PEMWE）作为大规模制氢的有前途的技术引起了广泛关注。然而，开发用于酸性析氧反应（OER）的稳定和活性催化剂的挑战限制了整体水分解效率。最近，基于金属有机骨架（MOF）的材料由于其固有的多孔结构和出色的可调性而被广泛用作酸性 OER 的电催化剂。在这篇综述文章中，重点介绍了酸性 OER 机制和设计高效基于 MOF 的酸性 OER 电催化剂的先进策略。最后，讨论了在酸性介质中探索稳健的基于 MOF 的 OER 电催化剂的挑战和前景。