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Neuropilin 1-targeted near-infrared fluorescence probes for tumor diagnosis
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2023-02-23 , DOI: 10.1016/j.bmcl.2023.129196
Shuai Qin 1 , Qingzhu Liu 2 , Ke Li 2 , Ling Qiu 2 , Minhao Xie 1 , Jianguo Lin 2
中文翻译：
用于肿瘤诊断的神经毡蛋白 1 靶向近红外荧光探针
更新日期：2023-02-26
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2023-02-23 , DOI: 10.1016/j.bmcl.2023.129196
Shuai Qin 1 , Qingzhu Liu 2 , Ke Li 2 , Ling Qiu 2 , Minhao Xie 1 , Jianguo Lin 2
Affiliation
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Two neuropilin 1 (NRP1)-targeted near-infrared fluorescence probes for tumor imaging were synthesized via click reaction. These two probes achieve excellent solubility and less aggregation. Importantly, they were able to rapidly target NRP1-overexpressing tumors and had long retention within tumors. Additionally, QS-1 with appropriate hydrophilicity displays higher tumor to muscle (T/M) ratio. And QS-1 can be easily modified with other functional group, and serve as a platform for constructing dual-modal or dual-targeting probes.
中文翻译：
用于肿瘤诊断的神经毡蛋白 1 靶向近红外荧光探针
通过点击反应合成了两种用于肿瘤成像的神经毡蛋白 1 (NRP1) 靶向近红外荧光探针。这两种探针实现了优异的溶解性和较少的聚集。重要的是，它们能够快速靶向 NRP1 过度表达的肿瘤，并在肿瘤内长期保留。此外，具有适当亲水性的QS-1显示出更高的肿瘤与肌肉 (T/M) 比率。并且QS-1可以很容易地与其他功能基团进行修饰，并作为构建双模态或双靶向探针的平台。
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