Injectable, Hierarchically Degraded Bioactive Scaffold for Bone Regeneration,ACS Applied Materials & Interfaces

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Injectable, Hierarchically Degraded Bioactive Scaffold for Bone Regeneration
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-02-24 , DOI: 10.1021/acsami.2c18824
Jixing Ye _{1,

2} , Ningyuan Liu _{1,

2} , Zongxin Li _{1,

2} , Liehua Liu _{1,

2} , Ming Zheng _{1,

2} , Xueping Wen _{1,

2} , Nan Wang _{1,

2} , Yanqin Xu ₃ , Biemin Sun ₃ , Qiang Zhou _{1,

2}

Affiliation

Bioactive materials play vital roles in the repair of critical bone defects. However, bone tissue engineering and regenerative medicine are still challenged by the need to repair bone defects evenly and completely. In this study, we functionally simulated the natural creeping substitution process of autologous bone repair by constructing an injectable, hierarchically degradable bioactive scaffold with a composite hydrogel, decalcified bone matrix (DBM) particles, and bone morphogenetic protein 2. This composite scaffold exhibited superior mechanical properties. The scaffold promoted cell proliferation and osteogenic differentiation through multiple signaling pathways. The hierarchical degradation rates of the crosslinked hydrogel and DBM particles accelerated tissue ingrowth and bone formation with a naturally woven bone-like structure in vivo. In the rat calvarial critical defect repair model, the composite scaffold provided even and complete repair of the entire defect area while also integrating the new and host bone effectively. Our results indicate that this injectable, hierarchically degradable bioactive scaffold promotes bone regeneration and provides a promising strategy for evenly and completely repairing the bone defects.

中文翻译：

用于骨再生的可注射、分级降解的生物活性支架

生物活性材料在关键骨缺损的修复中起着至关重要的作用。然而，骨组织工程和再生医学仍然面临着均匀和完全修复骨缺损的挑战。在这项研究中，我们通过构建具有复合水凝胶、脱钙骨基质 (DBM) 颗粒和骨形态发生蛋白 2 的可注射、分级可降解生物活性支架，在功能上模拟了自体骨修复的自然蠕变替代过程。这种复合支架表现出优异的机械性能特性。该支架通过多种信号通路促进细胞增殖和成骨分化。交联水凝胶和 DBM 颗粒的分级降解率加速了组织向内生长和骨形成，并在体内形成了天然编织的类骨结构。在大鼠颅骨关键缺损修复模型中，复合支架对整个缺损区域进行了均匀、完整的修复，同时有效整合了新骨和宿主骨。我们的结果表明，这种可注射、可分级降解的生物活性支架可促进骨再生，并为均匀、完全修复骨缺损提供了一种有前途的策略。

更新日期：2023-02-24

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