Langerhans cells in the skin and oral mucosa: Brothers in arms?,European Journal of Immunology

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Langerhans cells in the skin and oral mucosa: Brothers in arms?
European Journal of Immunology ( IF 4.5 ) Pub Date : 2023-02-22 , DOI: 10.1002/eji.202149499
Anna Brand ₁ , Avi-Hai Hovav ₂ , Björn E Clausen _{1,

3}

Affiliation

The skin and the oral mucosa represent interfaces to the environment that are constantly exposed to pathogens and harmless foreign antigens such as commensal bacteria. Both barrier organs share the presence of Langerhans cells (LC), distinctive members of the heterogeneous family of antigen-presenting dendritic cells (DC) that have the unique ability to promote tolerogenic as well as inflammatory immune responses. While skin LC have been extensively studied in the past decades, less is known about the function of oral mucosal LC. Despite similar transcriptomic signatures, skin and oral mucosal LC differ greatly in their ontogeny and development. In this review article, we will summarize the current knowledge on LC subsets in the skin compared to the oral mucosa. We will discuss the similarities and differences in their development, homeostasis, and function in the two barrier tissues, including their interaction with the local microbiota. In addition, this review will update recent advances on the role of LC in inflammatory skin and oral mucosal diseases.

中文翻译：

皮肤和口腔粘膜中的朗格汉斯细胞：战友？

皮肤和口腔粘膜是与环境的接触面，不断暴露于病原体和无害的外来抗原（例如共生细菌）。两个屏障器官都存在朗格汉斯细胞 (LC)，朗格汉斯细胞是抗原呈递树突细胞 (DC) 异质家族的独特成员，具有促进耐受性和炎症免疫反应的独特能力。虽然皮肤 LC 在过去几十年中得到了广泛的研究，但对于口腔粘膜 LC 的功能却知之甚少。尽管转录组学特征相似，但皮肤和口腔粘膜 LC 在个体发育和发育方面存在很大差异。在这篇综述文章中，我们将总结目前关于皮肤 LC 亚群与口腔粘膜相比的知识。我们将讨论它们在发育、体内平衡、以及在两个屏障组织中的功能，包括它们与当地微生物群的相互作用。此外，本综述将更新 LC 在炎症性皮肤和口腔粘膜疾病中作用的最新进展。

更新日期：2023-02-22

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