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Wearable Dual-Signal NH3 Sensor with High Sensitivity for Non-invasive Diagnosis of Chronic Kidney Disease
Langmuir ( IF 3.7 ) Pub Date : 2023-02-22 , DOI: 10.1021/acs.langmuir.2c03347 Hongjie Chen 1, 2 , Junlin Chen 1, 3, 4 , Yang Liu 1, 3 , Bingrui Li 1, 2, 3 , Haofei Li 1, 2, 3 , Xing Zhang 1, 2, 3 , Chuhan Lv 1, 3, 4 , Hua Dong 1, 2, 3, 4
Langmuir ( IF 3.7 ) Pub Date : 2023-02-22 , DOI: 10.1021/acs.langmuir.2c03347 Hongjie Chen 1, 2 , Junlin Chen 1, 3, 4 , Yang Liu 1, 3 , Bingrui Li 1, 2, 3 , Haofei Li 1, 2, 3 , Xing Zhang 1, 2, 3 , Chuhan Lv 1, 3, 4 , Hua Dong 1, 2, 3, 4
Affiliation
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NH3 gas in human exhaled breath contains abundant physiological information related to human health, especially chronic kidney disease (CKD). Unfortunately, up to now, most wearable NH3 sensors show inevitable defects (low sensitivity, easy to be interfered by the environment, etc.), which may lead to misdiagnosis of CKD. To solve the above dilemma, a nanoporous, heterogeneous, and dual-signal (optical and electrical) wearable NH3 sensor mask is developed successfully. More specifically, a polyacrylonitrile/bromocresol green (PAN/BCG) nanofiber film as a visual NH3 sensor and a polyacrylonitrile/polyaniline/reduced graphene oxide (PAN/PANI/rGO) nanofiber film as a resistive NH3 sensor are constructed. Due to the high specific surface area and abundant NH3 binding sites of these two nanofiber films, they exhibit good NH3 sensing performance. However, although the visual NH3 sensor (PAN/BCG nanofiber film) is simple without the need of any detecting facilities and quite stable when temperature and humidity change, it shows poor sensitivity and resolution. In comparison, the resistive NH3 sensor (PAN/PANI/rGO nanofiber film) is of high sensitivity, fast response, and good resolution, but its electrical signal is easily interfered by the external environment (such as humidity, temperature, etc.). Considering that the sensing principles between a visual NH3 sensor and resistive NH3 sensor are significantly different, a wearable dual-signal NH3 sensor containing both a visual NH3 sensor and resistive NH3 sensor is further explored. Our data prove that the two sensing signals in this dual-signal NH3 sensor mask can not only work well without interference with each other but also complement each other to improve the sensing accuracy, indicating its potential application in non-invasive diagnosis of CKD.
中文翻译：
用于慢性肾脏病无创诊断的高灵敏度可穿戴双信号 NH3 传感器
人体呼出气中的NH 3气体含有丰富的与人体健康相关的生理信息，尤其是慢性肾脏病（CKD）。不幸的是，到目前为止，大多数可穿戴NH 3传感器都存在不可避免的缺陷（灵敏度低、易受环境干扰等），这可能导致CKD的误诊。为了解决上述困境，成功开发了一种纳米多孔、异质、双信号（光学和电学）可穿戴 NH 3传感器口罩。更具体地说，聚丙烯腈/溴甲酚绿 (PAN/BCG) 纳米纤维薄膜作为可视 NH 3传感器，聚丙烯腈/聚苯胺/还原氧化石墨烯 (PAN/PANI/rGO) 纳米纤维薄膜作为电阻 NH 3传感器被构造。由于这两种纳米纤维薄膜具有高比表面积和丰富的NH 3结合位点，因此表现出良好的NH 3传感性能。然而，视觉NH 3传感器（PAN/BCG纳米纤维膜）虽然结构简单，无需任何检测设备，在温湿度变化时也相当稳定，但灵敏度和分辨率较差。相比之下，电阻式NH 3传感器（PAN/PANI/rGO纳米纤维薄膜）灵敏度高、响应快、分辨率好，但其电信号容易受到外界环境（如湿度、温度等）的干扰。 . 考虑到视觉 NH 3传感器和电阻式 NH之间的传感原理3传感器明显不同，进一步探索了包含视觉 NH 3传感器和电阻式 NH 3传感器的可穿戴双信号NH 3 传感器。我们的数据证明，这种双信号NH 3传感器面罩中的两种传感信号不仅可以很好地工作而不会相互干扰，而且可以相互补充以提高传感精度，表明其在CKD无创诊断中的潜在应用。
更新日期：2023-02-22
中文翻译：
用于慢性肾脏病无创诊断的高灵敏度可穿戴双信号 NH3 传感器
人体呼出气中的NH 3气体含有丰富的与人体健康相关的生理信息，尤其是慢性肾脏病（CKD）。不幸的是，到目前为止，大多数可穿戴NH 3传感器都存在不可避免的缺陷（灵敏度低、易受环境干扰等），这可能导致CKD的误诊。为了解决上述困境，成功开发了一种纳米多孔、异质、双信号（光学和电学）可穿戴 NH 3传感器口罩。更具体地说，聚丙烯腈/溴甲酚绿 (PAN/BCG) 纳米纤维薄膜作为可视 NH 3传感器，聚丙烯腈/聚苯胺/还原氧化石墨烯 (PAN/PANI/rGO) 纳米纤维薄膜作为电阻 NH 3传感器被构造。由于这两种纳米纤维薄膜具有高比表面积和丰富的NH 3结合位点，因此表现出良好的NH 3传感性能。然而，视觉NH 3传感器（PAN/BCG纳米纤维膜）虽然结构简单，无需任何检测设备，在温湿度变化时也相当稳定，但灵敏度和分辨率较差。相比之下，电阻式NH 3传感器（PAN/PANI/rGO纳米纤维薄膜）灵敏度高、响应快、分辨率好，但其电信号容易受到外界环境（如湿度、温度等）的干扰。 . 考虑到视觉 NH 3传感器和电阻式 NH之间的传感原理3传感器明显不同，进一步探索了包含视觉 NH 3传感器和电阻式 NH 3传感器的可穿戴双信号NH 3 传感器。我们的数据证明，这种双信号NH 3传感器面罩中的两种传感信号不仅可以很好地工作而不会相互干扰，而且可以相互补充以提高传感精度，表明其在CKD无创诊断中的潜在应用。
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