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Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial
Pharmacology Research & Perspectives ( IF 2.9 ) Pub Date : 2023-02-22 , DOI: 10.1002/prp2.1066
Gongchen Duan 1 , Haiyan Lan 1 , Weifeng Shan 1 , Yini Wu 1 , Qiaomin Xu 1 , Xiaoli Dong 1 , Peiyi Mei 1 , Minji You 1 , Linfei Jin 1 , Jimin Wu 1
Affiliation  

Ciprofol is a newly developed intravenous anesthetic agent with improved pharmacokinetic properties. Compared to propofol, ciprofol exhibits stronger binding to the GABAA receptor and elicits a greater enhancement of GABAA receptor-mediated neuronal currents in vitro. The aims of the present clinical trials were to examine the safety and efficacy of different doses of ciprofol for induction of general anesthesia in elderly patients. A total of 105 elderly patients undergoing elective surgery were randomized, in a 1:1:1 ratio, to receive one of three sedation regimens: (1) the C1 group (0.2 mg/kg ciprofol), (2) the C2 group (0.3 mg/kg ciprofol), (3) the C3 group (0.4 mg/kg ciprofol). The primary outcome was the incidence of various adverse events, including hypotension, hypertension, bradycardia, tachycardia, hypoxemia, and injection pain. The secondary outcomes of efficacy were the success rate of general anesthesia induction, the time to anesthesia induction, and the frequency of remedial sedation was recorded in each group. Adverse events occurred in 13 patients (37%) in group C1, 8 patients (22%) in group C2, and 24 patients (68%) in group C3. Compared with group C2, the total incidence of adverse events was significantly higher in group C1 and group C3 (p < .001).The success rate of general anesthesia induction in the three groups was 100%. Compared with group C1, the frequency of remedial sedation was significantly lower in group C2 and group C3. The outcomes demonstrated that ciprofol at a dose of 0.3 mg/kg has good safety and efficacy in the induction of general anesthesia in elderly patients. Overall, ciprofol is a new and viable option for the induction of general anesthesia in elderly patients undergoing elective surgery.

中文翻译:

不同剂量环丙酚用于老年患者全身麻醉诱导的临床效果:随机对照试验

环丙酚是一种新开发的静脉麻醉剂,具有改善的药代动力学特性。与丙泊酚相比,环丙酚与 GABAA 受体的结合更强,并在体外引起 GABAA 受体介导的神经元电流的更大增强。本临床试验的目的是检查不同剂量的环丙酚用于老年患者全身麻醉诱导的安全性和有效性。共有 105 名接受择期手术的老年患者按 1:1:1 的比例随机接受三种镇静方案之一:(1) C1 组(0.2 mg/kg 环丙酚),(2) C2 组( 0.3 mg/kg 环丙酚),(3)C3 组(0.4 mg/kg 环丙酚)。主要结局是各种不良事件的发生率,包括低血压、高血压、心动过缓、心动过速、低氧血症和注射痛。疗效的次要结果是全身麻醉诱导的成功率、麻醉诱导的时间以及每组记录的补救性镇静频率。C1组有13名患者(37%)发生不良事件,C2组有8名患者(22%)发生不良事件,C3组有24名患者(68%)发生不良事件。与C2组相比,C1组和C3组的不良事件总发生率显着较高(p  <.001)。三组全身麻醉诱导成功率均为100%。与C1组相比,C2组和C3组的治疗性镇静频率显着较低。结果表明,0.3 mg/kg剂量的环丙酚用于老年患者全身麻醉诱导具有良好的安全性和有效性。总体而言,环丙酚是择期手术老年患者全身麻醉诱导的一种新的可行选择。
更新日期:2023-02-22
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