具有抗胃酸和缓释功能的粘膜粘附水凝胶用于改善 DSS 诱导的溃疡性结肠炎,Journal of Agricultural and Food Chemistry

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具有抗胃酸和缓释功能的粘膜粘附水凝胶用于改善 DSS 诱导的溃疡性结肠炎
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-02-22 , DOI: 10.1021/acs.jafc.2c07777
Hai-Bo Huang ₁ , Wei Gong ₂ , Yi-Yang Hou ₁ , Wan-Ying He ₁ , Ran Wang ₁ , Xin-Chuang Wang ₁ , Jiang-Ning Hu _{1,

2}

Affiliation

粘膜粘附水凝胶具有多功能特性，如抗胃酸和在肠道中持续释放药物，非常适合用于炎症性肠病 (IBD) 的口服治疗。与IBD治疗的一线药物相比，多酚被证明具有更好的疗效。我们最近报道没食子酸 (GA) 能够形成水凝胶。然而，这种水凝胶在体内容易降解，粘附性差。为了解决这个问题，目前的研究引入了海藻酸钠 (SA) 以形成没食子酸/海藻酸钠混合水凝胶 (GAS)。正如预期的那样，GAS 水凝胶在肠道中显示出出色的抗酸、粘膜粘附和持续降解特性。体外研究表明，GAS 水凝胶显着减轻了小鼠的溃疡性结肠炎 (UC)。GAS 组的结肠长度 (7.75 ± 0.38 cm) 明显长于 UC 组 (6.12 ± 0.25 cm)。UC组疾病活动指数（DAI）值为（5.5±0.57），明显高于GAS组（2.5±0.65）。GAS水凝胶还可以抑制炎性细胞因子的表达，调节巨噬细胞极化，改善肠粘膜屏障功能。所有这些结果表明，GAS 水凝胶是治疗 UC 的理想候选药物。

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Mucoadhesive Hydrogel with Anti-gastric Acid and Sustained-Release Functions for Amelioration of DSS-Induced Ulcerative Colitis

Mucoadhesive hydrogels with multifunctional properties such as gastric acid resistance and sustained drug release in the intestinal tract are highly desirable for the oral treatment of inflammatory bowel diseases (IBDs). Polyphenols are proven to have great efficacies compared with the first-line drugs for IBD treatments. We recently reported that gallic acid (GA) was capable of forming a hydrogel. However, this hydrogel is prone to easy degradation and poor adhesion in vivo. To tackle this problem, the current study introduced sodium alginate (SA) to form a gallic acid/sodium alginate hybrid hydrogel (GAS). As expected, the GAS hydrogel showed excellent antiacid, mucoadhesive, and sustained degradation properties in the intestinal tract. In vitro studies demonstrated that the GAS hydrogel significantly alleviated ulcerative colitis (UC) in mice. The colonic length of the GAS group (7.75 ± 0.38 cm) was significantly longer than that of the UC group (6.12 ± 0.25 cm). The disease activity index (DAI) value of the UC group was (5.5 ± 0.57), which was markedly higher than that of the GAS group (2.5 ± 0.65). The GAS hydrogel also could inhibit the expression of inflammatory cytokines, regulating macrophage polarization and improving the intestinal mucosal barrier functions. All these results indicated that the GAS hydrogel was an ideal candidate for oral treatment of UC.

更新日期：2023-02-22

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