Nanomedicine-Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy,Advanced Materials

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Nanomedicine-Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy
Advanced Materials ( IF 27.4 ) Pub Date : 2023-02-22 , DOI: 10.1002/adma.202212259
Xinran Song _{1,

2} , Qin Zhang ₃ , Meiqi Chang ₄ , Li Ding ₅ , Hui Huang _{1,

2} , Wei Feng _{1,

2} , Tianming Xu _{6,

7} , Yu Chen _{1,

2}

Affiliation

Nanomedicine-enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US-based biomedicine, overcoming the shortcomings of traditional microbubbles and optimizing the design of contrast and sonosensitive agents. The single-faceted summary of available US-related therapies is still a significant drawback. Here, The proposal of a comprehensive review on the recent advances of sonosensitive nanomaterials in advancing four US-related biological applications and disease theranostics is aimed. In addition to the mostly explored nanomedicine-enabled/augmented sonodynamic therapy (SDT), the summary and discussion of other sono-therapies and progresses/achievements are relatively lacking, including sonomechanical therapy (SMT), sonopiezoelectric therapy (SPT), and sonothermal therapy (STT). The design concepts of the specific sono-therapies based on nanomedicines are initially introduced. Furthermore, the representative paradigms for nanomedicine-enabled/enhanced US therapies are elaborated according to therapeutic principles and diversity. This review provides an updated and comprehensive review of the field of nanoultrasonic biomedicine, and comprehensively discusses the progress of versatile ultrasonic disease treatments. Finally, the deep discussion on the facing challenges and prospects is expected to promote the emergence and establishment of a new branch of US biomedicine through the rational combination of nanomedicine and US clinical biomedicine.

中文翻译：

纳米医学支持的声机械、声压电、声动力和声热疗法

纳米医学/增强超声（美国）医学是跨学科研究的一个独特领域，专注于设计和工程功能纳米系统，以解决美国生物医学中的挑战性问题，克服传统微泡的缺点并优化对比和声敏的设计代理。对可用的美国相关疗法的单方面总结仍然是一个重大缺陷。在此，该提案旨在全面审查声敏纳米材料在推进与美国相关的四种生物应用和疾病治疗诊断方面的最新进展。除了目前探索最多的纳米医学/增强声动力疗法（SDT）外，对其他声疗法及其进展/成就的总结和讨论相对缺乏，包括声机械疗法（SMT）、声压电疗法（SPT）和声热疗法（STT）。初步介绍了基于纳米药物的特定声波疗法的设计理念。此外，根据治疗原理和多样性详细阐述了纳米医学启用/增强的美国疗法的代表性范例。本综述对纳米超声生物医学领域进行了更新和全面的综述，并全面讨论了多功能超声疾病治疗的进展。最后，对面临的挑战和前景进行深入探讨，有望通过纳米医学与美国临床生物医学的合理结合，推动美国生物医学新分支的出现和建立。

更新日期：2023-02-22

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