K2S2O8-Induced [4+2] Annulation of Tertiary Anilines and Alkenes toward Tetrahydroquinolines,Organic Letters

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K2S2O8-Induced [4+2] Annulation of Tertiary Anilines and Alkenes toward Tetrahydroquinolines
Organic Letters ( IF 4.9 ) Pub Date : 2023-02-22 , DOI: 10.1021/acs.orglett.2c04335
Jianguo Hu _{1,

2} , Shengchun Wang ₃ , Bin Li ₂ , Aiwen Lei _{1,

3}

Affiliation

Due to the unique physicochemical properties of heterocyclic compounds, their construction is one of the central issues in synthetic chemistry. Here, we report a K₂S₂O₈-induced protocol for constructing tetrahydroquinolines from bulk chemicals (alkenes and anilines). The merit of this method has been demonstrated by its operational simplicity, wide scope, mild conditions, and transition-metal-free system.

中文翻译：

K2S2O8 诱导的 [4+2] 叔苯胺和烯烃对四氢喹啉的成环反应

由于杂环化合物独特的物理化学性质，其构建是合成化学中的核心问题之一。在这里，我们报告了用于从大宗化学品（烯烃和苯胺）构建四氢喹啉的K ₂ S ₂ O _{8诱导方案。}该方法的优点已通过其操作简单、适用范围广、条件温和和无过渡金属体系得到证明。

更新日期：2023-02-22

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