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Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Dressings for Chronic Wound Management
ACS Omega ( IF 3.7 ) Pub Date : 2023-02-20 , DOI: 10.1021/acsomega.2c06806 Dhruvi Solanki 1 , Preksha Vinchhi 1 , Mayur M Patel 1
ACS Omega ( IF 3.7 ) Pub Date : 2023-02-20 , DOI: 10.1021/acsomega.2c06806 Dhruvi Solanki 1 , Preksha Vinchhi 1 , Mayur M Patel 1
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Wound healing is a complex and dynamic physiological process consisting of a series of cellular and molecular events that initiate immediately after a tissue lesion, to reconstruct the skin layer. It is indubitable that patients with chronic wounds, severely infected wounds, or any metabolic disorder of the wound microenvironment always endure severe pain and discomfort that affect their quality of life. It is essential to treat chronic wounds for conserving the physical as well as mental well-being of affected patients and for convalescing to improve their quality of life. For supporting and augmenting the healing process, the selection of pertinent wound dressing is essential. A substantial reduction in healing duration, disability, associated cost, and risk of recurrent infections can be achieved via engineering wound dressings. Hydrogels play a leading role in the path of engineering ideal wound dressings. Hydrogels, comprising water to a large extent, providing a moist environment, being comfortable to patients, and having biocompatible and biodegradable properties, have found their success as suitable wound dressings in the market. The exploitation of hydrogels is increasing perpetually after substantiation of their broader therapeutic actions owing to their resemblance to dermal tissues, their capability to stimulate partial skin regeneration, and their ability to incorporate therapeutic moieties promoting wound healing. This review entails properties of hydrogel supporting wound healing, types of hydrogels, cross-linking mechanisms, design considerations, and formulation strategies of hydrogel engineering. Various categories of hydrogel wound dressing fabricated recently are discussed based on their gel network composition, degradability, and physical and chemical cross-linking mechanisms, which provide an outlook regarding the importance of tailoring the physicochemical properties of hydrogels. The examples of marketed hydrogel wound dressings are also incorporated along with the future perspectives and challenges associated with them.
中文翻译：
用于慢性伤口管理的水凝胶敷料的设计考虑、配方方法和战略进展
伤口愈合是一个复杂而动态的生理过程，由一系列细胞和分子事件组成，这些事件在组织损伤后立即开始，以重建皮肤层。毋庸置疑，慢性伤口、严重感染伤口或任何伤口微环境代谢紊乱的患者都会承受剧烈的疼痛和不适，影响他们的生活质量。治疗慢性伤口对于保护受影响患者的身心健康以及康复以改善他们的生活质量至关重要。为了支持和促进愈合过程，选择合适的伤口敷料至关重要。通过工程伤口敷料可以大大减少愈合时间、残疾、相关成本和反复感染的风险。水凝胶在工程理想伤口敷料的道路上发挥着主导作用。水凝胶在很大程度上包含水，提供潮湿的环境，使患者感到舒适，并具有生物相容性和可生物降解的特性，已在市场上成功地用作合适的伤口敷料。由于水凝胶与真皮组织的相似性、它们刺激部分皮肤再生的能力以及它们结合促进伤口愈合的治疗部分的能力，在证实其更广泛的治疗作用后，水凝胶的开发不断增加。这篇综述涉及支持伤口愈合的水凝胶的特性、水凝胶的类型、交联机制、设计考虑因素和水凝胶工程的配方策略。最近制造的各种类型的水凝胶伤口敷料基于它们的凝胶网络组成、可降解性以及物理和化学交联机制进行了讨论，这提供了关于定制水凝胶物理化学性质的重要性的展望。还结合了市售水凝胶伤口敷料的示例以及与之相关的未来前景和挑战。
更新日期：2023-02-20
中文翻译：
用于慢性伤口管理的水凝胶敷料的设计考虑、配方方法和战略进展
伤口愈合是一个复杂而动态的生理过程，由一系列细胞和分子事件组成，这些事件在组织损伤后立即开始，以重建皮肤层。毋庸置疑，慢性伤口、严重感染伤口或任何伤口微环境代谢紊乱的患者都会承受剧烈的疼痛和不适，影响他们的生活质量。治疗慢性伤口对于保护受影响患者的身心健康以及康复以改善他们的生活质量至关重要。为了支持和促进愈合过程，选择合适的伤口敷料至关重要。通过工程伤口敷料可以大大减少愈合时间、残疾、相关成本和反复感染的风险。水凝胶在工程理想伤口敷料的道路上发挥着主导作用。水凝胶在很大程度上包含水，提供潮湿的环境，使患者感到舒适，并具有生物相容性和可生物降解的特性，已在市场上成功地用作合适的伤口敷料。由于水凝胶与真皮组织的相似性、它们刺激部分皮肤再生的能力以及它们结合促进伤口愈合的治疗部分的能力，在证实其更广泛的治疗作用后，水凝胶的开发不断增加。这篇综述涉及支持伤口愈合的水凝胶的特性、水凝胶的类型、交联机制、设计考虑因素和水凝胶工程的配方策略。最近制造的各种类型的水凝胶伤口敷料基于它们的凝胶网络组成、可降解性以及物理和化学交联机制进行了讨论，这提供了关于定制水凝胶物理化学性质的重要性的展望。还结合了市售水凝胶伤口敷料的示例以及与之相关的未来前景和挑战。
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