To improve the mechanical properties of CoCrNi system multicomponent alloys, we prepared a series of (CoCrNi)_100-x(TiV)_x (x = 5, 10, 20, 30, and 40) multicomponent alloys by simultaneously adding Ti and V elements into the CoCrNi-based alloy at a fixed stoichiometric ratio (1:1). Results showed that the phase components of the prepared alloys with x ≤ 10 were composed of a typical single face-centered cubic phase. The elements in the alloy (CoCrNi)₉₅(TiV)₅ were uniformly distributed, whereas the Ti in the (CoCrNi)₉₀(TiV)₁₀ alloy was segregated in the based microstructure. The yield strength of (TiV)₁₀ alloy (678 MPa) was approximately two times that of (TiV)₅ alloy (371 MPa), with non-sacrificed plasticity (> 50%). The enhancement of yield strength of the alloy was attributed to precipitation strengthening caused by the Ti segregation and the solid solution strengthening of TiV. Stiff phases σ, η, and body-centered cubic were formed in the alloys with higher TiV content and distributed in both the dendrites and inter-dendrites regions, thus increasing the compression strength of the alloy. The maximum compression strength was 2220 MPa of the alloy with x = 40.