A series of 3‑chloro-4-(pyridin-2-ylmethoxy) aniline derivatives were synthesized and biologically evaluated for antitumor activities. Among all the compounds, the antitumor activity of 7k was twice than Imatinib on HL-60, K-562, MCF-7 and A498 cell lines. Mechanistic studies revealed that compound 7k displayed significant anti-proliferation, anti-migration and anti-invasion effects on K-562. Molecular docking studies showed that compounds 7k could interact with BCR-ABL kinase. These findings suggest that compound 7k can be considered as an antitumor drug candidate which deserves to be further investigated for personalized cancer therapy.

合成了一系列 3-chloro-4-(pyridin-2-ylmethoxy) 苯胺衍生物，并对其抗肿瘤活性进行了生物学评估。在所有化合物中，7k对 HL-60、K-562、MCF-7 和 A498 细胞系的抗肿瘤活性是 Imatinib 的两倍。机理研究表明，化合物7k对 K-562 具有显着的抗增殖、抗迁移和抗侵袭作用。分子对接研究表明，化合物7k可以与 BCR-ABL 激酶相互作用。这些发现表明，化合物 7k可被视为抗肿瘤候选药物，值得进一步研究以用于个性化癌症治疗。