背景
柘树是一种多年生植物,马尾藻是一种棕色海藻,具有许多潜在益处,包括抗癌、抗炎和抗氧化活性。然而, C. tricuspidata和S. fusiforme对毛发生长的功效尚未阐明。因此,本研究检测了C. tricuspidata和S. fusiforme提取物对 C57BL/6 小鼠毛发生长
的影响。
结果
ImageJ 证明,与对照组相比,饮用C. tricuspidata和/或S. fusiforme提取物并在皮肤上涂抹可显着增加 C57BL/6 小鼠背部皮肤的毛发生长率。组织学分析证实,与对照小鼠相比,饮用C. tricuspidata和/或S. fusiforme提取物并皮肤涂抹 21 天,治疗的 C57BL/6 小鼠背部皮肤上的毛囊长度显着增加。 RNA 测序分析显示,毛发生长周期相关因子(生长期因子),如连环蛋白 Beta 1 ( Ctnnb1 ) 和血小板衍生生长因子 ( Pdgf ) 仅通过三尖瓣毛提取物上调(> 两倍),而血管内皮生长因子( Vegf)和Wnts在治疗小鼠中通过C. tricuspidata或S. fusiforme应用而上调(与对照小鼠相比)。此外,与对照小鼠相比,当通过皮肤和饮用模式给予治疗小鼠时,
制瘤素 M( Osm ,一种退行期-休止期因子)被C. tricuspidata下调(< 0.5 倍) 。
结论
我们的结果表明,C. tricuspidata和/或S. fusiforme提取物通过上调毛发生长初期因子基因(包括β-catenin、Pdgf、Vegf和Wnts)和下调毛发生长终期因子基因(包括Osm )而显示出潜在的毛发生长功效。 /6只小鼠。研究结果表明,C. tricuspidata和/或S. fusiforme提取物是治疗脱发的潜在候选药物。
"点击查看英文标题和摘要"
Effects of Cudrania tricuspidata and Sargassum fusiforme extracts on hair growth in C57BL/6 mice
Background
Cudrania tricuspidata is a perennial plant, and Sargassum fusiforme is a brown seaweed with numerous potential benefits, including anticancer, anti-inflammatory, and antioxidant activities. However, the efficacies of C. tricuspidata and S. fusiforme on hair growth have not yet been elucidated. Therefore, the present study examined the effects of C. tricuspidata and S. fusiforme extracts on hair growth in C57BL/6 mice.
Results
ImageJ demonstrated that drinking and skin application of C. tricuspidata and/or S. fusiforme extracts significantly increased the hair growth rate in the dorsal skin of C57BL/6 mice compared to the control group. Histological analysis confirmed that drinking and skin application of C. tricuspidata and/or S. fusiforme extracts for 21 days significantly increased the length of hair follicles on the dorsal skin of treated C57BL/6 mice compared to that in the control mice. RNA sequencing analysis revealed that hair growth cycle-related factors (anagen factors) such as Catenin Beta 1 (Ctnnb1) and platelet-derived growth factor (Pdgf) were upregulated (> twofold) only by C. tricuspidate extracts, whereas vascular endothelial growth factor (Vegf) and Wnts were upregulated by both C. tricuspidata or S. fusiforme applications in treated mice (compared to the control mice). In addition, oncostatin M (Osm, a catagen-telogen factor) was downregulated (< 0.5 fold) by C. tricuspidata when administered via both skin and drinking mode in treated mice compared to that in control mice.
Conclusions
Our results suggest that C. tricuspidata and/or S. fusiforme extracts show potential hair growth efficacy by upregulating anagen factor genes, including β-catenin, Pdgf, Vegf, and Wnts, and downregulating catagen-telogen factor genes, including Osm, in C57BL/6 mice. The findings suggest that C. tricuspidata and/or S. fusiforme extracts are potential drug candidates to treat alopecia.