Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2023-02-17 , DOI: 10.1038/s41392-023-01331-9
Qian Ding 1, 2, 3 , Wei Hu 1 , Ran Wang 1 , Qinyan Yang 1 , Menglin Zhu 1 , Meng Li 1 , Jianghong Cai 1 , Peter Rose 4 , Jianchun Mao 5 , Yi Zhun Zhu 1, 6
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Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force. In the past few decades, RA has attracted increased attention from researchers, the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA, which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets. The current review intends to provide a comprehensive overview of RA, including a general introduction to the disease, historical events, epidemiology, risk factors, and pathological process, highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms, including genetic factors, epigenetic factors, summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA. therapeutic interventions including approved drugs, clinical drugs, pre-clinical drugs, and cutting-edge therapeutic technologies. These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future.
中文翻译:
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类风湿性关节炎的信号通路:对靶向治疗的影响
类风湿性关节炎 (RA) 是一种无法治愈的全身性自身免疫性疾病。疾病进展导致关节畸形和相关的功能丧失,这会严重影响患者的生活质量并增加劳动力的损失。在过去的几十年里,RA越来越受到研究者的关注,RA中异常的信号通路是RA诊断和治疗中非常重要的研究领域,为理解这一复杂疾病和开发新的RA相关干预措施提供了重要证据目标。目前的审查旨在提供 RA 的全面概述,包括疾病的一般介绍、历史事件、流行病学、危险因素和病理过程,重点介绍该疾病及各种信号通路和分子机制的主要研究进展,包括遗传因素、表观遗传因素,总结了确定RA新信号通路和治疗RA的新抑制剂的最新进展。治疗干预包括批准药物、临床药物、临床前药物和尖端治疗技术。这些发展有望推动新的战略性靶向治疗的进展,并有望在未来为 RA 治疗选择提供新思路。和尖端的治疗技术。这些发展有望推动新的战略性靶向治疗的进展,并有望在未来为 RA 治疗选择提供新思路。和尖端的治疗技术。这些发展有望推动新的战略性靶向治疗的进展,并有望在未来为 RA 治疗选择提供新思路。