Immunosuppressive Bibenzyl-phenylpropane Hybrids from Dendrobium devonianum,Chemistry & Biodiversity

当前位置： X-MOL 学术 › Chem. Biodivers. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Immunosuppressive Bibenzyl-phenylpropane Hybrids from Dendrobium devonianum
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-02-16 , DOI: 10.1002/cbdv.202201185
Rui Zhan ₁ , Xin-Yue Zhang ₁ , Zhi-Yuan Li ₂ , Bo Liu ₁ , Ye-Gao Chen ₁

Affiliation

Two new bibenzyl-phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1–9 were specifically immunosuppressive to T lymphocytes with IC₅₀ values ranging from 0.41 to 9.4 μM, of which compounds 1 (IC₅₀=1.62 μM) and 2 (IC₅₀=0.41 μM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively.

中文翻译：

来自石斛兰的免疫抑制联苄基-苯基丙烷杂化物

从Dendrobium devonianum Paxt 的地上部分分离出两种新的联苄基-苯基丙烷杂化物，树酚 A 和 B（1和2），以及九种已知的联苄。它们的结构是通过广泛的光谱方法和甲基化确定的。生物测定表明，化合物1-9对 T 淋巴细胞具有特异性免疫抑制作用，IC ₅₀值范围为 0.41 至 9.4 μM，其中化合物1（IC ₅₀ =1.62 μM）和化合物2（IC ₅₀ =0.41 μM）是有前途的 T 淋巴细胞免疫抑制剂选择性指数分别为 19.9 和 79.5 的淋巴细胞。

更新日期：2023-02-16

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南