A Small-Molecule Fluorescence Probe for Nuclear ATP,Angewandte Chemie International Edition

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A Small-Molecule Fluorescence Probe for Nuclear ATP
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-02-15 , DOI: 10.1002/anie.202300580
Umme Tamima ₁ , Sourav Sarkar ₁ , Md Reyazul Islam ₂ , Anushree Shil ₁ , Kyeong Hwan Kim ₁ , Ye Jin Reo ₁ , Yong Woong Jun ₁ , Hasanul Banna ₂ , Soobin Lee ₁ , Kyo Han Ahn ₁

Affiliation

The first small-molecule probe for nuclear ATP is reported. The probe, a Zn^II complex of a push-full type benzocoumarin dye bearing a dipicolylamine ligand, reversibly binds to nuclear ATP with a turn-on fluorescence response. Using the probe, we observed markedly higher levels of nuclear ATP in organ tissues of a tumor-xenografted mouse by two-photon microscopy, which is ascribed to aggressive cell progression in the mitosis phase.

中文翻译：

用于核 ATP 的小分子荧光探针

报道了第一个用于核 ATP 的小分子探针。该探针是一种带有二吡啶胺配体的推全型苯并香豆素染料的 Zn ^II复合物，可逆地结合核 ATP 并具有开启荧光响应。使用探针，我们通过双光子显微镜观察到肿瘤异种移植小鼠器官组织中明显更高水平的核 ATP，这归因于有丝分裂期的侵袭性细胞进展。

更新日期：2023-02-15

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