Research conducted over the past several decades has revolutionized our understanding of the role of the immune system in neural and psychological development and function across the life span. Our goal in this review is to introduce this dynamic area of research to a psychological audience and highlight its relevance for clinical psychology. We begin by introducing the basic physiology of immune-to-brain signaling and the neuroimmune network, focusing on inflammation. Drawing from preclinical and clinical research, we then examine effects of immune activation on key psychological domains, including positive and negative valence systems, social processes, cognition, and arousal (fatigue, sleep), as well as links with psychological disorders (depression, posttraumatic stress disorder, anxiety, schizophrenia). We also consider psychosocial stress as a critical modulator of neuroimmune activity and focus on early life adversity. Finally, we highlight psychosocial and mind–body interventions that influence the immune system and may promote neuroimmune resilience.

中文翻译：

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心理神经免疫学：免疫-大脑通讯简介及其对临床心理学的影响


过去几十年进行的研究彻底改变了我们对免疫系统在整个生命周期中神经和心理发育和功能中的作用的理解。我们在本综述中的目标是向心理学受众介绍这一充满活力的研究领域，并强调其与临床心理学的相关性。我们首先介绍免疫到大脑信号传导和神经免疫网络的基本生理学，重点介绍炎症。然后，我们利用临床前和临床研究，检查免疫激活对关键心理领域的影响，包括积极和消极的价子系统、社会过程、认知和唤醒（疲劳、睡眠），以及与心理障碍（抑郁症、创伤后应激障碍、焦虑、精神分裂症）的联系。我们还将社会心理压力视为神经免疫活动的关键调节剂，并关注早期生活逆境。最后，我们强调了影响免疫系统并可能促进神经免疫弹性的社会心理和身心干预。