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Synthesis of 1-Substituted 3H-Naphtho[1,2,3-de]quinoline-2,7-diones
Doklady Chemistry ( IF 0.8 ) Pub Date : 2023-02-15 , DOI: 10.1134/s0012500822700112 S. A. Chernenko , A. L. Shatsauskas , A. S. Kostyuchenko , A. S. Fisyuk
中文翻译:
1-取代 3H-萘并[1,2,3-de]喹啉-2,7-二酮的合成
更新日期:2023-02-16
Doklady Chemistry ( IF 0.8 ) Pub Date : 2023-02-15 , DOI: 10.1134/s0012500822700112 S. A. Chernenko , A. L. Shatsauskas , A. S. Kostyuchenko , A. S. Fisyuk
Abstract
A method for preparing 1-tosyl-3H-naphtho[1,2,3-de]quinoline-2,7-diones by the reaction of N-(9,10-anthraquinon-1-yl)chloroacetamide with sodium p-toluenesulfinate has been developed. Nucleophilic substitution of the tosyl group by nitrogen and oxygen nucleophiles has been found to proceed under mild conditions. The corresponding 1-substituted 3H-naphtho[1,2,3-de]quinoline-2,7-diones have been obtained by the reaction of these compounds with amines, phenol, sodium hydroxide, and sodium azide.
中文翻译:
1-取代 3H-萘并[1,2,3-de]喹啉-2,7-二酮的合成
摘要
一种N- (9,10-蒽醌-1-基)氯乙酰胺与对-钠反应制备1-甲苯磺酰-3H-萘并[1,2,3-脱]喹啉-2,7-二酮的方法开发了甲苯亚磺酸盐。已发现氮和氧亲核试剂对甲苯磺酰基的亲核取代在温和条件下进行。相应的 1-取代 3 H-萘并[1,2,3-脱]喹啉-2,7-二酮已通过这些化合物与胺、苯酚、氢氧化钠和叠氮化钠的反应获得。