用于生物医学应用的高度亲水油胺修饰的超顺磁性氧化铁纳米粒子,ACS Applied Nano Materials

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用于生物医学应用的高度亲水油胺修饰的超顺磁性氧化铁纳米粒子
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-02-15 , DOI: 10.1021/acsanm.2c04006
Niki Karouta _{1,

2} , Yannis V. Simos _{2,

3} , Georgia Basina ₄ , Konstantinos Spyrou _{1,

2} , Mohammed Subrati ₁ , Alexandra V. Chatzikonstantinou _{2,

5} , Mohamed Amen Hammami ₆ , Vasileios Tzitzios ₇ , Saeed M. Alhassan ₄ , Yasser Al Wahedi _{4,

8} , Alexios P. Douvalis ₉ , George C. Hadjipanayis ₁₀ , Konstantinos Tsamis _{1,

2,

11} , Evangelia Dounousi _{1,

2,

11} , Georgios S. Markopoulos ₁₂ , Sofia Bellou ₁₃ , Vasilios Georgakilas ₁₄ , Dimitrios Peschos _{1,

2,

11} , Zili Sideratou ₇ , Haralambos Stamatis _{2,

5} , Dimitrios P. Gournis _{1,

2} , Emmanuel P. Giannelis ₆

Affiliation

Department of Materials Science and Engineering, University of Ioannina, Ioannina 45110, Greece
Nanomedicine and Nanobiotechnology Research Group, University of Ioannina, Ioannina 45110, Greece
Laboratory of Physiology, School of Health Sciences, Department of Medicine, University of Ioannina, Ioannina 45110, Greece
Department of Chemical Engineering, Khalifa University of Science and Technology, Sas Al Nakhl Campus, P.O. Box 127788, Abu Dhabi 127788, UAE
Department of Biological Applications and Technologies, University of Ioannina, Ioannina 45110, Greece
Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, United States
Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”, Agia Parasevi-Attikis, Athens 15310, Greece
Abu Dhabi Maritime Academy, Abu Dhabi Ports, Abu Dhabi, United Arab Emirates
Department of Physics, University of Ioannina, Ioannina 45110, Greece
Department of Physics & Astronomy, University of Delaware, Newark, Delaware 19716, United States
Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece
Neurosurgical Institute, University of Ioannina, Ioannina 45110, Greece
Confocal Laser scanning Microscopy Unit, Network of Research Supporting Laboratories (NRSL), University of Ioannina, Ioannina 45110, Greece
Department of Materials Science, University of Patras, Rio 26504, Patras, Greece

超顺磁性氧化铁纳米粒子 (SPION) 正在成为生物医学应用的重要载体。本研究展示了一种基于“剪发”反应的新策略，旨在设计高亲水性和功能性纳米粒子。合成后的 SPION 直径约为 4 nm，由于其表面存在的油胺分子 (o-SPION) 对它们进行了表面修饰，因此显示出超有机行为。应用于油胺分子双键的“修整”产生以羧基终止的较短链，所得纳米颗粒具有高亲水性、水分散性和功能性（h-SPION）。针对三种不同的细胞系研究了 h-SPION 的生物学行为，揭示了对癌细胞的选择性细胞毒作用。这种设计纳米粒子表面特性的新方法可以导致新一代功能纳米材料的开发。此外，h-SPIONs 可以在未来的生物医学系统中演变成一个新的和不断扩大的磁性纳米材料家族。

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更新日期：2023-02-15

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