Liquid Metal-Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization,Advanced Functional Materials

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Liquid Metal-Enabled Microspheres with High Drug Loading and Multimodal Imaging for Artery Embolization
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-02-13 , DOI: 10.1002/adfm.202209413
Xiyu Zhu ₁ , Minghui Duan ₁ , Lin Zhang ₂ , Jiasheng Zhao ₁ , Sheng Yang ₁ , Rui Shen ₁ , Sen Chen ₁ , Linlin Fan ₃ , Jing Liu _{1,

3}

Affiliation

The drug-eluting microspheres that have been widely used in clinical treatments such as chemoembolization commonly suffer from inadequate drug loading and tracking difficulties. With inherent high density and excellent biocompatibility, liquid metal (LM) has been explored at the frontiers of medical imaging and clinical therapy. Herein, multifunctional microspheres (SA/LM/DOX) are reported with high drug loading and multimodal imaging by adsorbing silanized LM particles on sulfonated agarose microspheres (SA), which are capable of heating and accelerating drug release under an 808 nm near-infrared (NIR) laser. The negative SA microspheres can adsorb more positive drugs such as doxorubicin (DOX) up to 104 mg DOX per mL microspheres. It deserves to be mentioned that SA/LM/DOX microspheres have the function of multimodal imaging under computed tomography (CT), magnetic resonance imaging (MRI), and B-scan ultrasonography (US), which significantly facilitate location tracking during the embolization process. In rabbit ear central artery embolization, these microspheres are smoothly injected into the intended location of the vessel and successfully blocked blood flow, and eventually led to necrosis of rabbit ear. Overall, these microspheres with high drug loading capacity and multimodal contrast properties are promising candidates to be developed as new products for future clinical medicine.

中文翻译：

具有高载药量和动脉栓塞多模式成像的液态金属微球

广泛应用于化疗栓塞等临床治疗的药物洗脱微球普遍存在载药量不足和追踪困难等问题。液态金属 (LM) 具有固有的高密度和优异的生物相容性，已在医学成像和临床治疗的前沿进行探索。在此，通过将硅烷化 LM 颗粒吸附在磺化琼脂糖微球 (SA) 上，多功能微球 (SA/LM/DOX) 具有高载药量和多模式成像，能够在 808 nm 近红外 (近红外）激光。负 SA 微球可以吸附更多的正药物，如多柔比星 (DOX)，每毫升微球最多可吸附 104 mg DOX。值得一提的是，SA/LM/DOX微球具有计算机断层扫描（CT）、磁共振成像（MRI）和B超（US）下的多模态成像功能，显着促进了栓塞过程中的位置追踪. 在兔耳中心动脉栓塞术中，这些微球被顺利地注射到血管的预定位置并成功阻断了血流，最终导致兔耳坏死。总的来说，这些具有高载药量和多模态对比特性的微球有望成为未来临床医学新产品的开发候选者。在兔耳中心动脉栓塞术中，这些微球被顺利地注射到血管的预定位置并成功阻断了血流，最终导致兔耳坏死。总的来说，这些具有高载药量和多模态对比特性的微球有望成为未来临床医学新产品的开发候选者。在兔耳中心动脉栓塞术中，这些微球被顺利地注射到血管的预定位置并成功阻断了血流，最终导致兔耳坏死。总的来说，这些具有高载药量和多模态对比特性的微球有望成为未来临床医学新产品的开发候选者。

更新日期：2023-02-13

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