Synthesis of P-Stereogenic Phosphine Oxides via Nickel-Catalyzed Asymmetric Cross-Coupling of Secondary Phosphine Oxides with Alkenyl and Aryl Bromides,Angewandte Chemie International Edition

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Synthesis of P-Stereogenic Phosphine Oxides via Nickel-Catalyzed Asymmetric Cross-Coupling of Secondary Phosphine Oxides with Alkenyl and Aryl Bromides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-02-14 , DOI: 10.1002/anie.202300011
Chuanyong Wang ₁ , Xiaobo Hu ₁ , Cheng Xu ₁ , Qiangqiang Ge ₁ , Qingliang Yang ₁ , Jianqi Xiong ₁ , Wei-Liang Duan _{1,

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Affiliation

A nickel-catalyzed asymmetric C(sp²)−P cross-coupling for the synthesis of P-stereogenic phosphine oxides under mild conditions is reported. The enantioselective alkenylation/arylation of racemic secondary phosphine oxides with alkenyl/aryl bromides provided P-stereogenic phosphine oxides with high enantioselectivities of up to 99 % ee.

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