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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation
Advanced Materials ( IF 27.4 ) Pub Date : 2023-02-13 , DOI: 10.1002/adma.202209692 Tingting Hu 1 , Weicheng Shen 1 , Fanqi Meng 2 , Shuqing Yang 1 , Shilong Yu 3 , Hai Li 3 , Qinghua Zhang 2 , Lin Gu 4 , Chaoliang Tan 5, 6 , Ruizheng Liang 1
Advanced Materials ( IF 27.4 ) Pub Date : 2023-02-13 , DOI: 10.1002/adma.202209692 Tingting Hu 1 , Weicheng Shen 1 , Fanqi Meng 2 , Shuqing Yang 1 , Shilong Yu 3 , Hai Li 3 , Qinghua Zhang 2 , Lin Gu 4 , Chaoliang Tan 5, 6 , Ruizheng Liang 1
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Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other therapeutic strategies. However, the current sonosensitizers used for SDT normally exhibit low activity for ultrasound (US)-induced reactive oxygen species (ROS) generation. Herein, the crystalline-to-amorphous phase transformation is reported as a simple but powerful strategy to engineer ultrathin 2D CoW-LDH and NiW-LDH nanosheets as highly efficient sonosensitizers for SDT. The phase transformation of CoW-LDH and NiW-LDH nanosheets from polycrystalline to amorphous ones is achieved through a simple acid etching treatment. Importantly, compared with the polycrystalline one, the amorphous CoW-LDH (a-CoW-LDH) nanosheets possess higher ROS generation activity under US irradiation, which is ≈17 times of the commercial TiO2 sonosensitizer. The results suggest that the enhanced performance of ultrathin a-CoW-LDH nanosheets for US-induced ROS generation may be attributed to the phase transformation-induced defect generation and electronic structure changes. After polyethylene glycol modification, the a-CoW-LDH nanosheets can serve as a high-efficiency sonosensitizer for SDT to achieve cell death in vitro and tumor eradication in vivo under US irradiation.
中文翻译：
通过晶相到非晶相转变提高基于二维层状双氢氧化物纳米片的声敏剂的声动力学癌症治疗性能
与其他治疗策略相比，声动力疗法 (SDT) 具有优越的优势，因此一直是一种很有前途的癌症治疗方式。然而，目前用于 SDT 的声敏剂通常对超声波 (US) 诱导的活性氧 (ROS) 生成表现出低活性。在此，据报道，结晶到非晶的相变是一种简单但有效的策略，可将超薄 2D CoW-LDH 和 NiW-LDH 纳米片设计为 SDT 的高效声敏剂。CoW-LDH 和 NiW-LDH 纳米片从多晶到非晶的相变是通过简单的酸蚀刻处理实现的。重要的是，与多晶纳米片相比，非晶 CoW-LDH (a-CoW-LDH) 纳米片在 US 照射下具有更高的 ROS 生成活性，2声敏剂。结果表明，超薄 a-CoW-LDH 纳米片对 US 诱导的 ROS 生成的增强性能可能归因于相变诱导的缺陷生成和电子结构变化。经过聚乙二醇修饰后，a-CoW-LDH 纳米片可作为 SDT 的高效声敏剂，在超声照射下实现体外细胞死亡和体内肿瘤根除。
更新日期：2023-02-13
中文翻译：
通过晶相到非晶相转变提高基于二维层状双氢氧化物纳米片的声敏剂的声动力学癌症治疗性能
与其他治疗策略相比，声动力疗法 (SDT) 具有优越的优势，因此一直是一种很有前途的癌症治疗方式。然而，目前用于 SDT 的声敏剂通常对超声波 (US) 诱导的活性氧 (ROS) 生成表现出低活性。在此，据报道，结晶到非晶的相变是一种简单但有效的策略，可将超薄 2D CoW-LDH 和 NiW-LDH 纳米片设计为 SDT 的高效声敏剂。CoW-LDH 和 NiW-LDH 纳米片从多晶到非晶的相变是通过简单的酸蚀刻处理实现的。重要的是，与多晶纳米片相比，非晶 CoW-LDH (a-CoW-LDH) 纳米片在 US 照射下具有更高的 ROS 生成活性，2声敏剂。结果表明，超薄 a-CoW-LDH 纳米片对 US 诱导的 ROS 生成的增强性能可能归因于相变诱导的缺陷生成和电子结构变化。经过聚乙二醇修饰后，a-CoW-LDH 纳米片可作为 SDT 的高效声敏剂，在超声照射下实现体外细胞死亡和体内肿瘤根除。
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