Hydrogenation still faces unmet technical challenges in relation to heterogeneous reactions and potential safety issues. In this work, a continuous flow Pd/C-catalyzed hydrogenation of 2-(4-nitrophenyl) butanoic acid (NBA) was developed within a micropacked-bed reactor. Catalytic hydrogenation of NBA involves the interaction of gaseous and liquid reactants on solid catalysts and the mechanism has not been clearly reported. Therefore, the Langmuir-Hinshelwood-Hougen-Watson (LHHW) approach was used to investigate the kinetics and attempted to explain the possible mechanistic path. The effects of internal diffusion, external diffusion, and salt formation were characterized, the intrinsic kinetic model was established and corresponding parameters were obtained. The model showed that the reaction proceeds through the dual site molecular adsorption of reactant specie and NBA can be reduced to 2-(4-aminophenyl) butanoic acid (ABA) either through the generation of hydroxylamine intermediates or directly.

加氢在多相反应和潜在安全问题方面仍面临未解决的技术挑战。在这项工作中，在微填充床反应器中开发了2-(4-硝基苯基) 丁酸 ( NBA ) 的连续流动 Pd/C 催化氢化。NBA的催化加氢涉及气态和液态反应物在固体催化剂上的相互作用，其机理尚未明确报道。因此，Langmuir-Hinshelwood-Hougen-Watson ( LHHW) 方法用于研究动力学并试图解释可能的机械路径。表征了内扩散、外扩散和成盐的影响，建立了内在动力学模型并获得了相应的参数。该模型表明，反应通过反应物的双位点分子吸附进行，NBA可以通过生成羟胺中间体或直接还原为 2-(4-氨基苯基) 丁酸 ( ABA) 。